Publications by authors named "Masashi Ikebe"
Article Synopsis
- The study focuses on the activation of rat liver microsomal glutathione S-transferase (MGST1) by a specific protease found in the liver, which was identified as hepsin.
- Hepsin is characterized as a type II transmembrane serine protease, and when incubated with MGST1, it significantly boosts MGST1 activity by 3-4.5 times over several days.
- Analysis reveals that this incubation leads to the formation of MGST1 dimers and degradation fragments, indicating that hepsin acts both to activate and degrade MGST1 in liver microsomes.
