Publications by authors named "Masashi Fujioka"
Article Synopsis
- The study investigated the connection between inactivated influenza vaccination and viral load in children under 6 in Japan over several flu seasons.
- Researchers analyzed 1,185 influenza-positive children and found that the viral loads did not significantly differ based on vaccination status, with median values around 5.5 for all groups.
- Key factors impacting viral load included specific influenza subtypes and children's temperature, indicating that vaccination status did not play a role in viral load differences.
Article Synopsis
- The study investigates the changing clinical features of pediatric COVID-19 in Japan as a result of emerging variants, particularly focusing on persistent symptoms following infection.
- Analysis of 5,411 pediatric cases showed a significant increase in seizure occurrence during the Omicron wave, rising to 13.4% in younger children.
- The research highlights that 3.2% of children experienced symptoms lasting over 28 days post-infection, suggesting a need for further studies to monitor long-term effects.
Article Synopsis
- This study investigates how prior vaccination affects the effectiveness of the current influenza vaccine in children aged 1-5 years during the 2016/17 and 2017/18 seasons in Japan.
- The research looked at 799 influenza cases and 1196 controls, categorizing their vaccination status into six groups to analyze vaccine effectiveness (VE). Overall, the effectiveness varied by vaccination history, but one- and two-dose VEs were significant regardless of prior vaccination.
- The findings suggest that even with prior vaccinations, the current season's vaccines maintain effectiveness, as demonstrated by varying VE percentages among different vaccination groups.
Article Synopsis
- * Nearly 48% of the pediatric patients were asymptomatic, and a large portion had mild symptoms; most cases were linked to positive cases in the household, suggesting household transmission is prevalent.
- * The research indicated that nationwide school closures had little effect on the transmission of COVID-19 among children, highlighting the need for measures focused on reducing household transmission to prevent the spread of the virus.
Article Synopsis
- The study addresses the challenge of misinformation about vaccinations online and evaluates a Vaccine Information Statement (VIS) developed by the Japan Pediatric Society to aid parental decision-making regarding immunizations.
- Conducted across 18 centers in Japan, the research involved an intervention group that received the VIS alongside a questionnaire, while a control group only received the questionnaire, assessing vaccination rates and parental knowledge.
- Results showed no significant difference in vaccination rates between the two groups, but the VIS did positively impact parents' vaccine knowledge and perceptions, indicating it may enhance understanding of immunizations for infants.
Objective Baloxavir marboxil is a novel anti-influenza drug reported to have an early antiviral effect, although it also causes the appearance of variant viruses with a reduced susceptibility to baloxavir. In Japan, four neuraminidase inhibitors (NAIs) have been commonly used to treat patients with influenza. In clinical practice, the differences in the effects of baloxavir and NAIs have not been sufficiently examined.
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- After the 2009 A/H1N1 pandemic, two new influenza drugs, laninamivir and peramivir, were introduced in Japan, prompting an analysis of prescription trends for four neuraminidase inhibitors over eight years.
- A survey in Osaka Prefecture collected data from influenza patients about their demographics, symptoms, and medications.
- Results showed laninamivir was favored for patients aged 10 and older, while oseltamivir was preferred for those under 10, with all drugs demonstrating similar effectiveness and differences in fever response based on influenza type and patient age.
Article Synopsis
- After the 2009 A/H1N1 pandemic, Japan introduced two new influenza medications, laninamivir and peramivir, which are now commonly used alongside oseltamivir.
- A study during the 2012-2013 flu season in Osaka showed that while laninamivir use increased, none of the medications significantly impacted fever or symptoms.
- Despite vaccinated patients having longer fever durations, the type of influenza virus was the only factor linked to quicker fever alleviation, not vaccination status.
This study investigated the significance of urological surgical intervention for viral hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A total of 1, 024 patients underwent allo-HSCT at our medical center between January 2006 and July 2014. In the 6 patients (0.
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- In Japan, four neuraminidase inhibitors (NAIs) are used to treat influenza A and B, and understanding patient backgrounds is crucial for effective medication selection.
- A study in Osaka collected data via postcard questionnaires from patients prescribed NAIs, analyzing factors associated with early fever relief.
- Results showed that for patients under 10, influenza type influenced fever alleviation, with laninamivir showing a tendency for greater effectiveness compared to oseltamivir, although NAIs overall were not linked to significant fever relief.
Article Synopsis
- A study evaluated the effectiveness and safety of a 2009 pandemic influenza vaccine in Japanese adolescents aged 13 to 18, with 111 participants receiving two doses of the vaccine.
- Results showed high seroprotection (91%) and seroconversion rates (78%) after the first dose, indicating strong immune response, while no serious side effects were reported.
- The findings highlighted that existing antibodies before vaccination affected the immune response, suggesting pre-vaccination antibody levels should be considered in future vaccine studies.
Between November 2008 and March 2010, we performed initial division of the left renal vein occluded by the tumor thrombus in six cases of left renal cancer at Toranomon Hospital. The left renal vein was completely occluded by the tumor thrombus in all cases. In order to ligate the left renal artery first behind the dilated left renal vein, we must dissect the left kidney with arterial blood flow.
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- A 30-year-old woman was hospitalized due to fatigue and a noticeable mass in her left side, with tests revealing a large kidney tumor and tumor thrombus extending into her heart.
- The surgical challenge involved safely removing the tumor while managing significant blood flow issues caused by the tumor blocking the left renal vein and artery.
- The complex surgery, which lasted over 9 hours and involved significant blood loss, successfully removed both the kidney and tumor thrombus without major complications, aside from a lymphocele in the abdomen.
Article Synopsis
- Deafness is a rare but significant complication of mumps virus infection, with an estimated incidence of 0.5 to 5.0 cases per 100,000, though some reports indicate it may be higher, especially in endemic areas like Japan.
- A study conducted across 40 pediatric practices from 2004 to 2006 assessed the hearing loss incidence in children with mumps and involved hearing screenings at home.
- Out of 7,400 children evaluated, 7 had confirmed severe and unilateral hearing loss, and all were unvaccinated, indicating a higher incidence than previously thought and highlighting the importance of mumps vaccination to prevent deafness.*
Article Synopsis
- The study investigates the rare occurrence of undetected colorectal cancers in patients undergoing laparoscopic cholecystectomy (LC) for benign gallbladder diseases.
- Out of 473 patients, only 2 (0.4%) were found to have coinciding colorectal cancers post-surgery, with no preoperative symptoms or significant laboratory indications.
- Although the incidence is very low, the findings suggest that careful preoperative assessments and thorough intraoperative examinations could help reduce the chances of missing colorectal cancers during LC.