Publications by authors named "Masaru Hatano"
Article Synopsis
- * The study included 230 SSc patients and trained a convolutional neural network to identify PH, achieving an AUC of 0.826, which is slightly better than cardiologists' assessments (0.804).
- * The deep learning model not only effectively detected PH but also showed a promising prognosis with a 5-year survival rate of around 83-85% for patients diagnosed with PH, indicating its potential clinical utility.
Background: Approximately 10% of hypertrophic cardiomyopathy (HCM) patients have left ventricular systolic dysfunction (end-stage HCM) leading to severe heart-failure; however, risk stratification to identify patients at risk of progressing to end-stage HCM remains insufficient.
Objectives: In this study, the authors sought to elucidate whether the coexistence of other cardiovascular disease (CVD)-related variants is associated with progression to end-stage HCM in patients with HCM harboring pathogenic or likely pathogenic (P/LP) sarcomeric variants.
Methods: The authors performed genetic analysis of 83 CVD-related genes in HCM patients from a Japanese multicenter cohort.
Article Synopsis
- Clonal hematopoiesis of indeterminate potential (CHIP) is shown to worsen outcomes in patients with nonischemic dilated cardiomyopathy (DCM) despite being well-known for its negative impacts on atherosclerotic disease.
- Researchers analyzed 198 DCM patients using advanced genetic sequencing to find both germline mutations linked to cardiomyopathy and somatic mutations in CHIP driver genes, discovering 25 CHIP mutations in 22 patients.
- The study concluded that CHIP is an independent risk factor for cardiac issues in DCM, contributing to worsened heart function and structural damage, and that genetic mutations can help predict patient prognosis.
Background Context: Domino osteoporotic vertebral fractures (OVFs) involve multiple OVFs occurring simultaneously or sequentially, before healing of the initial OVFs. However, the risk factors and long-term clinical outcomes of domino OVFs are unclear.
Purpose: To identify the risk factors associated with domino OVFs and to assess their impact on patients' quality of life (QOL).
Background: The contemporary outcome of balloon pulmonary angioplasty (BPA) and pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) are unclear.
Objectives: This study aimed to clarify the characteristics and outcomes of CTEPH patients treated with BPA and PEA in Japan.
Methods: Among 1,270 participants enrolled between 2018 and 2023 in the CTEPH AC (Chronic Thromboembolic Pulmonary Hypertension Anticoagulant) registry, a Japanese nationwide CTEPH registry, 369 treatment-naive patients (BPA strategy: n = 313; PEA strategy: n = 56) and 690 on-treatment patients (BPA strategy: n = 561; PEA strategy: n = 129) were classified according to the presence of prior reperfusion therapy.
Study Design: Prospective cohort study.
Purpose: This study aimed to identify the optimal preoperative bone health assessment for adult spinal deformity (ASD) surgery through correlation analysis between intraoperative pedicle screw (PS) insertion torque and various bone quality measures, including bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry (DEXA), Hounsfield unit (HU) by computed tomography (CT), and vertebral bone quality (VBQ) score by magnetic resonance imaging.
Overview Of Literature: Existing data on optimal assessment tools for ASD surgery are limited.
Background: Decreased diffusing capacity of the lungs for carbon monoxide (DLco) is associated with microvascular damage in chronic thromboembolic pulmonary hypertension (CTEPH). Balloon pulmonary angioplasty (BPA) is an effective treatment for CTEPH, but the efficacy of BPA in patients with CTEPH with low DLco remains unclear because BPA does not directly address microvascular damage. This study investigates the influence of microvasculopathy on BPA in CTEPH according to DLco.
View Article and Find Full Text PDFLymphocytic myocarditis (LM) is primarily triggered by various factors including viral infections and subsequent immune responses. While rare, some patients with LM experience recurrence with a life-threatening fulminant form. Although combining steroids and immunosuppressants, such as azathioprine and mycophenolate mofetil, has demonstrated favourable outcomes in patients with LM, their efficacy is limited to the chronic phase.
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- * This study discusses a case where a leadless pacemaker was successfully implanted in a patient on VAD support, addressing safety concerns and showing no complications during a year of follow-up.
- * The findings suggest that combining a leadless pacemaker with a VAD could be a viable treatment option for complex cases of adult congenital heart disease (ACHD), although careful monitoring is essential.
Article Synopsis
- The study investigates the effectiveness of osteoanabolic agents (like teriparatide and romosozumab) and bisphosphonates in preventing subsequent domino osteoporotic vertebral fractures (OVF) within three months of the initial fracture.
- An analysis of 144 patients showed that the use of these agents did not significantly reduce the incidence of new fractures at both 3 and 12 months, although teriparatide and romosozumab lowered rates of unstable pseudarthrosis compared to bisphosphonates.
- The findings suggest that while osteoanabolic agents help with unstable pseudarthrosis, they do not outperform bisphosphonates in preventing new domino OVFs, indicating a need for a broader
Unlabelled: Inflammatory bowel disease (IBD) is a complex chronic inflammatory intestinal disease. The development of de novo IBD after solid organ transplantation with immunosuppressive agents has been rarely reported. We present the case of a 65-year-old man with repeated colitis after heart transplantation (HTx) who was diagnosed with Crohn's disease (CD).
View Article and Find Full Text PDFBackground: Whether comprehensive risk assessment predicts post-referral outcome in patients with pulmonary arterial hypertension (PAH) referred for lung transplantation (LT) in Japan is unknown.
Methods And Results: We retrospectively analyzed 52 PAH patients referred for LT. Risk status at referral was assessed using 3- and 4-strata models from the 2022 European Society of Cardiology and European Respiratory Society guidelines.
Article Synopsis
- A left ventricular assist device (LVAD) is used to treat advanced heart failure but can lead to late right heart failure (LRHF), which increases risks for patients.
- A study examined the right heart function of LVAD patients using a saline loading test one month after surgery, involving patients who underwent right heart catheterization.
- Findings showed that lower pulmonary artery pulsatility index and right ventricular stroke work index after saline loading were linked to higher chances of LRHF and death, indicating that these measurements could help anticipate post-operative risks.
Article Synopsis
- Right ventricular failure (RVF) can occur even years after left ventricular assist device (LVAD) implantation, as shown in a case involving a 12-year-old with heart issues.
- The patient initially had no risk factors, but experienced worsening RV function due to recurrent ventricular arrhythmias and progressive aortic insufficiency.
- Ultimately, he required heart transplantation nearly three years after receiving the LVAD, highlighting the need for long-term monitoring and management of RVF in LVAD patients.
Background: Among solid organ transplant (SOT) recipients, heart transplant (HT) recipients are at a higher risk of Toxoplasma gondii infection. As Toxoplasma seroprevalence varies by geographic location, updated local epidemiology is essential to guide preventive and therapeutic strategies. However, the Toxoplasma seroprevalence and incidence of post-transplant toxoplasmosis among SOT recipients in Japan are unknown.
View Article and Find Full Text PDFThe co-occurrence of dilated cardiomyopathy (DCM) and aortic dissection has been rarely reported. Here, we present the case of a patient with co-occurrence of DCM and aortic dissection, wherein multivessel coronary artery dissection eventually occurred, thereby leading to advanced heart failure. She suffered from co-occurrence of DCM and aortic dissection 6 years ago.
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- The increasing number of cancer patients with severe aortic stenosis and atrial fibrillation presents challenges in treatment, especially with the aging population.
- Transcatheter aortic valve replacement (TAVR) is a viable option for high-risk patients, including those with cancer, but antithrombotic therapy management is complex due to risks of thrombosis and bleeding.
- A case study highlights an elderly patient with metastatic pancreatic cancer and atrial fibrillation who experienced valve thrombosis and arterial embolism post-TAVR; successful treatment with warfarin after thrombectomy indicates a need for new management strategies for similar patients.
Background: Balloon pulmonary angioplasty (BPA) has beneficial effects on pulmonary hemodynamics, exercise capacity, and quality of life (QOL) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Recently, emerging evidence suggests a relationship between CTEPH and psychiatric disorders (PD). However, data on the clinical efficacy of BPA in CTEPH patients with PD are lacking.
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- Researchers investigated how DNA damage in heart tissue relates to treatment response and prognosis in heart failure patients.
- The study analyzed biopsy samples from 175 patients, measuring specific DNA damage markers to see how they correlated with the ability to improve heart function one year after treatment.
- Results showed that higher levels of DNA damage markers were linked to poorer treatment outcomes and a greater risk of serious heart-related events, suggesting that assessing DNA damage can help predict patient prognosis.