Publications by authors named "Masaru Cho"
Article Synopsis
- Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with no effective treatments, and the blood-brain barrier (BB(T)B) significantly limits the delivery of therapies.
- A study focused on the effects of nanomedicine size found that poly(ethylene glycol) (PEG)-grafted copolymers (gPEGs) at 10 nm provided optimal accumulation in GBM tissues, outperforming both larger gPEGs and conventional PEG in tumor targeting.
- The research highlights the potential of smaller-sized nanomedicines for improved passive targeting and deeper penetration in GBM, offering new avenues for treatment strategies.
Muscle-targeted drug delivery is a major challenge in nanomedicine. The extravasation of nanomedicines (or nanoparticles) from the bloodstream into muscle tissues is hindered by the continuous endothelium, the so-called blood-muscle barrier. This study aimed to evaluate the optimal size of macromolecular drugs for extravasation (or passive targeting) into muscle tissues.
View Article and Find Full Text PDFTo stabilize small interfering RNA (siRNA) in the bloodstream for systemic RNAi therapeutics, we previously fabricated ultrasmall siRNA nanocarriers that were sub-20 nm in hydrodynamic diameter, named as unit polyion complexes (uPICs), using two-branched poly(ethylene glycol)--poly(l-lysine) (bPEG-PLys). The blood retention time of uPICs is dramatically increased in the presence of free bPEG-PLys, suggesting dynamic stabilization of uPICs by free bPEG-PLys based on their equilibrium. Herein, we examined how the degree of polymerization of PLys (DP) affected the dynamic stability of uPICs in the bloodstream during prolonged circulation.
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