Publications by authors named "Masaoki Kin"
Article Synopsis
- A 48-year-old woman with early-stage breast cancer experienced severe thrombocytopaenia and moderate liver dysfunction after receiving trastuzumab emtansine as part of her treatment.
- She had a significantly low platelet count and elevated liver enzyme levels, leading to an emergency room visit due to symptoms like subcutaneous bleeding.
- The case suggests that trastuzumab emtansine could impact mature platelets and cause liver issues through its mechanism of disrupting microtubules in liver cells.
Article Synopsis
- The study investigates how the combination of platelet count and neutrophil-lymphocyte ratio (COP-NLR) affects the prognosis of advanced non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitor therapy combined with chemotherapy.
- A cohort of 88 NSCLC patients was analyzed, focusing on overall survival (OS) and treatment response based on COP-NLR scores measured three weeks after starting therapy.
- Findings reveal that lower baseline COP-NLR scores, as well as better Eastern Cooperative Oncology Group Performance Status (ECOG PS) and fewer distant metastatic sites, correlate with improved treatment responses and longer overall survival in these patients.
Article Synopsis
- The study analyzed factors predicting febrile neutropenia (FN) in esophageal cancer patients receiving DCF chemotherapy and pegfilgrastim for prevention.
- It involved 122 patients, with a focus on the incidence of FN after the first chemotherapy cycle, finding a 21% occurrence rate.
- Key predictors for FN identified were a geriatric nutritional risk index (GNRI) under 92 and a specific platelet-neutrophil-to-lymphocyte ratio, both significantly impacting neutrophil recovery and treatment intensity post-FN.
Adiponectin can protect against inflammation; one of the mechanisms involves direct, inhibition of macrophages (MΦ). We postulated that adiponectin anti-sense transgenic (AsTg) mice raised in our laboratory are prone to inflammation because of systemic low adiponectin levels. The writhing response to acetic acid was utilized as an in vivo inflammatory model, and using Ca(2)(+), response to the acid was exploited in vitro to evaluate the function of resident peritoneal MΦ.
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