Publications by authors named "Masao Jinno"
Article Synopsis
- A study was conducted to determine if administering granulocyte colony-stimulating factor (G-CSF) before assisted reproductive technology (ART) could improve embryo development and pregnancy rates in women with poor ovarian reserve.
- The trial included 100 women aged 20 to 42, where one group received G-CSF injections and the other did not; results showed that the G-CSF group had significantly higher fertilization, embryonic development, and pregnancy rates compared to controls.
- The cumulative live birth rate was 32% in the G-CSF group, compared to 14% in the control group, and infants born from the G-CSF group showed no congenital anomalies, indicating a positive association
Article Synopsis
- - The study investigates the effects of Hishi (Trapa bispinosa Roxb.) extract on advanced glycation end-products (AGE) and live birth rates in older women (ages 38-42) undergoing assisted reproductive technology (ART), finding that the Hishi group had a significantly higher live birth rate (47%) compared to the control group (16%).
- - This randomized controlled trial included 64 patients and compared outcomes between those receiving Hishi extract and those who didn't, measuring serum AGE levels and assessing fertility treatments up to live birth or embryo depletion.
- - Results indicated that Hishi not only lowered AGE levels but also improved oocyte potential and endometrial receptivity, establishing it as a significant factor associated with
Article Synopsis
- Advanced glycation end-products (AGE) play a significant role in infertility related to aging and diabetes, particularly in assisted reproductive technology (ART) outcomes.
- A study with 157 ART patients found that toxic AGE levels, specifically TAGE and pentosidine, negatively impacted key fertility metrics such as oocyte retrieval and ongoing pregnancy rates.
- Elevated TAGE in serum was directly correlated with poorer reproductive outcomes and associated with metabolic factors like BMI and insulin resistance, suggesting it may serve as a predictor for ART success.
Objective: Insulin resistance is associated with aging and stress, both common among patients repeatedly failing to conceive with in vitro fertilization (IVF repeaters). In the present study we examined whether low-dose metformin could improve the outcome in IVF repeaters without polycystic ovary syndrome (PCOS).
Design: Study I was a preliminary clinical trial aiming at defining indications for therapy; study II was a prospective randomized study.
Background: Use of antiretroviral drugs has reduced the mortality rate for HIV infection and many HIV-discordant couples wish to have children. It is possible for an HIV-infected man to father children without risk of HIV transmission if HIV-free spermatozoa can be obtained from his semen.
Methods: An improved swim-up method was used to collect HIV-free spermatozoa from the semen of HIV-positive males.
The present study was carried out to examine the predictive value of endocrine profiles as indicators of the sperm retrieval rate on testicular sperm extraction (TESE) in azoospermic men. Prior to TESE, the serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, testosterone, dihydrotestosterone (DHT), estradiol and 17 α-hydroxyprogesterone were measured and the sagittal cross-sections of the testis were acquired using ultrasonography. The sperm retrieval rates according to the cause of azoospermia were 40% for idiopathic azoospermia, and 100% for obstructive azoospermia, cryptorchidsm and ejaculatory disorder.
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