Publications by authors named "Masanori Nakajima"
Anti-myelin-associated glycoprotein (Anti-MAG) neuropathy and autoimmune nodopathies with antibodies targeting nodal or paranodal proteins have recently been reclassified as distinct conditions, separate from chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). This distinction is based on the clinical homogeneity observed in antibody-positive cases, their unique response to treatment compared to CIDP, and evidence indicating the pathogenic role of these autoantibodies. The significance of identifying conditions outside the CIDP category lies in the elucidation of their distinct pathological mechanisms and providing appropriate immunotherapy accordingly.
View Article and Find Full Text PDFArticle Synopsis
- * Four patients experienced inappropriate secretion of antidiuretic hormone, while one had a brain lesion and all benefited from sodium channel blockers to reduce certain seizure types.
- * Immunotherapy was effective in four out of five patients, with no relapses reported over a two-year follow-up, highlighting the importance of quick diagnosis and treatment for those with similar symptoms.
Article Synopsis
- This study investigated the effectiveness of 7-day Holter monitoring in detecting covert atrial fibrillation (AF) in patients who recently experienced an embolic stroke of undetermined source (ESUS).
- A total of 206 ESUS patients underwent Holter monitoring, revealing a 6.8% detection rate of AF, with specific biomarkers correlating with higher detection rates.
- Key predictive biomarkers included serum brain natriuretic peptide levels and counts of atrial premature contractions, both of which were consistently associated with AF detection in both the primary and validation cohorts.
Idiopathic basal ganglia calcification-1 (IBGC1) is an autosomal dominant disorder characterized by calcification in the basal ganglia, which can manifest a range of neuropsychiatric symptoms, including parkinsonism. We herein describe a 64-year-old Japanese IBGC1 patient with bilateral basal ganglia calcification carrying a novel variant (p.Val322Glufs*92).
View Article and Find Full Text PDFArticle Synopsis
- * An MRI revealed thickened meninges, suggesting conditions like hypertrophic pachymeningitis, but lab tests found no significant inflammation in his blood or cerebrospinal fluid.
- * After a biopsy showed thickening of the arachnoid membrane with microvessel enlargement but no inflammation, a repeated test confirmed APS, leading to successful antithrombotic treatment with warfarin that prevented further brain infarctions.
Article Synopsis
- * She had antibodies related to the cancer present in her blood and cerebrospinal fluid, resulting in paraneoplastic optic neuropathy and opsoclonus-ataxia syndrome.
- * After the SCLC was treated, her symptoms improved; the case highlights the need to test for specific antibodies and check for cancer in older patients with sudden vision issues.
This report describes the case of a 79-year-old man with aortic mobile thrombus in the ascending aorta, followed by a discussion of the pathologic basis of aortic mobile thrombus formation. The patient underwent replacement of the ascending aorta. Macroscopic examination revealed an aortic wall ulcer with cholesterol-rich atherosclerotic plaque under the aortic mobile thrombus.
View Article and Find Full Text PDFDetection of respiratory waveforms using non-contact electrodes during bathing.
Annu Int Conf IEEE Eng Med Biol Soc
March 2011
The aim of this study is to develop a method for measuring the respiratory waveform using non-contact electrodes during bathing. To determine the most appropriate electrode arrangement, we modeled a composite system consisting of a body submerged in bath water. We calculated the frequency dependence of the impedance amplitude using a three-dimensional finite difference method (3D-FDM).
View Article and Find Full Text PDF