Efficacy and safety of switching from topical latanoprost to bimatoprost in patients with normal-tension glaucoma.

Purpose: The aim of this study was to evaluate the efficacy and safety of bimatoprost in Japanese patients with normal-tension glaucoma (NTG) who showed insufficient response to latanoprost.

Methods: A prospective, nonrandomized study was conducted in patients with NTG, with ≤20% intraocular pressure (IOP) decrease from pretreatment baseline with latanoprost monotherapy who had been switched to bimatoprost. The IOP was measured at 4, 8, and 12 weeks after the switch to bimatoprost.

D-allose as ischemic retina injury inhibitor during rabbit vitrectomy.

Purpose: To investigate the protective effects of D-allose, a rare sugar, on pressure-induced ischemia during vitrectomy in the rabbit eye.

Methods: The rabbits underwent pars plana vitrectomy, and continuous intraocular irrigation at a perfusion pressure of 140 mmHg was performed for 45 min. Intraocular pressure was regulated by adjusting the height of a bottle of balanced saline solution containing D-allose.

Comparison of retinal nerve fiber layer thickness measurements using time domain and spectral domain optical coherence tomography, and visual field sensitivity.

Purpose: To investigate the relationship between the peripapillary retinal nerve fiber layer (RNFL) thickness, as measured by Stratus time domain optical coherence tomography (OCT) (Stratus OCT) and Cirrus spectral domain OCT (Cirrus HD-OCT), and the severity indices of the visual field (VF) defects in glaucoma patients.

Methods: This was a prospective, cross-sectional study. Correlations between the individual VF sensitivity at 52 test points and the Stratus OCT and Cirrus HD-OCT, which determined peripapillary RNFL thicknesses from 6 sectors, were calculated in 54 eyes with open-angle glaucoma and 22 normal control eyes.

Neuroprotection against retinal ischemia-reperfusion injury by blocking the angiotensin II type 1 receptor.

PURPOSE. To investigate the effects of an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II antagonist against retinal ischemia-reperfusion injury in the rat retina. METHODS.

Effect of trabeculectomy on intraocular pressure fluctuation with postural change in eyes with open-angle glaucoma.

Purpose: To investigate the effect of trabeculectomy on the intraocular pressure (IOP) fluctuations caused by the postural change in patients with open-angle glaucoma.

Methods: Prospective, nonrandomized study. Ten eyes of 10 patients with primary open-angle glaucoma and 3 eyes of 3 patients with normal-tension glaucoma who underwent trabeculectomy were studied.

Risk factors for developing avascular filtering bleb after fornix-based trabeculectomy with mitomycin C.

Purpose: To investigate risk factors for developing avascular filtering blebs after primary fornix-based trabeculectomy with mitomycin C (MMC).

Methods: One-year observational case series. Ninety eyes of 90 patients who underwent primary trabeculectomy with MMC and a fornix-based conjunctival flap were examined.