Publications by authors named "Masanori Kishimoto"
Article Synopsis
- - The study focuses on evaluating the effectiveness of virus inactivation methods used in the manufacturing process of porcine-derived gelatin, which is commonly used in pharmaceuticals and medical devices.
- - Researchers tested various model viruses and found that both chemical and heat treatments significantly reduced viral presence, achieving a log reduction value (LRV) greater than 4, indicating effective inactivation.
- - The findings confirm that implementing these treatment steps in gelatin production enhances safety by minimizing potential viral contamination in biomedical applications.
Bundles of engineered collagen microfibers are promising synthetic tendons as substitutes for autogenous grafts. The purpose of this study was to develop high-speed and continuous spinning of collagen microfibers that involves stretching of collagen stream. Our study revealed the 'critical fibrillogenesis concentration (CFC)' of neutralized collagen solutions, which is defined as the upper limit of the collagen concentration at which neutralized collagen molecules remain stable as long as they are cooled (⩽10 °C).
View Article and Find Full Text PDFTissue engineered scaffold was regarded as a promising approach instead of the autograft. In this study, small diameter electrospun collagen tubular scaffold with random continuous smooth nanofibers was successfully fabricated. However, the dissolution of collagen in concentrated aqueous (conc.
View Article and Find Full Text PDFDehydrothermal (DHT) treatment was used to improve the properties of collagen casings because of its non-cytotoxicity. Understanding the effects of DHT treatment on the structure and mechanical properties of collagen films is beneficial to developing satisfying collagen casings. Herein, DHT treatment with various temperatures (85-145 °C) and timescales (1-7 days) were investigated.
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