Differential Responses of Young and Old Erythrocytes Stored with Vitamin C and Vitamin E in Additive Solution-7.

Oxidative stress (OS) causes biochemical and morphological alterations in erythrocytes. The primary factors contributing to OS are aging and storage. Antioxidants significantly alleviate OS.

Attenuation of Oxidative Stress in Erythrocytes Stored with Vitamin C and l-Carnitine in Additive Solution-7.

Blood transfusion has advanced toward component therapy for specific requirements during trauma and surgery. Oxidative stress is induced in erythrocytes during storage. Hence, antioxidants as additives can be employed to counteract oxidative stress and enhance antioxidant defenses.

Synergistic activity of vitamin-C and vitamin-E to ameliorate the efficacy of stored erythrocytes.

Objectives: Erythrocytes are exposed to oxidative stress during storage and can be stored for up to 42 days (in AS-7) under blood bank conditions for transfusion. Vitamin-C and Vitamin-E have proved beneficial in diminishing oxidative stress. Therefore, this study aims to investigate the combined effects of Vitamin-C and Vitamin-E on erythrocytes during storage.