Publications by authors named "Masanari Ikeda"
Article Synopsis
- The X chromosome in mammals has a high concentration of genes related to germ cell development.
- A rat model for Becker muscular dystrophy (BMD) shows that males are infertile due to abnormal spermatids and a deletion of a specific gene linked to the dystrophin gene.
- This gene encodes a protein (DTSP) that is critical for normal spermatogenesis, and its absence in BMD rats is thought to contribute to their infertility.
Article Synopsis
- - Duchenne muscular dystrophy (DMD) is a genetic disorder that causes muscle damage, and the research explores in utero cell transplantation as a potential treatment option.
- - The study involved transplanting GFP-positive myoblasts and adipose-derived stem cells into pregnant mice (murine DMD models) using different methods but failed to detect any successful cell integration in muscle tissues.
- - Results indicated that both transplantation methods did not lead to cell engraftment, with adipose-derived stem cell transplants associated with a higher mortality rate in the fetuses.
Background: Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by a complete lack of dystrophin, which stabilizes the plasma membrane of myofibers. The orofacial function is affected in an advanced stage of DMD and this often leads to an eating disorder such as dysphagia. Dysphagia is caused by multiple etiologies including decreased mastication and swallowing.
View Article and Find Full Text PDFRhabdomyosarcoma (RMS) is an aggressive type of soft tissue sarcoma, and pleomorphic RMS is a rare subtype of RMS found in adult. p16 is a tumor suppressor which inhibits cell cycle. In human RMS, p16 gene is frequently deleted, but p16-null mice do not develop RMS.
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