Publications by authors named "Masanao Kaneko"

Article Synopsis
  • The study investigates black spots (BSs) seen during upper gastrointestinal endoscopy in patients undergoing eradication treatment, focusing on their patient demographics and clinicopathological features.* -
  • Data was collected from 6778 cases between 2017 and 2022, revealing that older age and certain medications are risk factors for BSs, which are linked to gastric atrophy and low infection levels.* -
  • The use of advanced imaging techniques identified iron deposition in BSs, suggesting they may indicate a lack of active inflammation and providing insights into their potential causes and formation mechanisms.*
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Although immunohistochemistry (IHC) for mismatch repair (MMR) proteins (MMR IHC) is used to identify DNA MMR status, universal screening of all patients with colorectal cancer (CRC) using a combination of both MMR IHC and genetic testing for the BRAFV600E mutation is limited in Japan. This study aimed to better understand the histopathological characteristics of CRCs, which exhibit both deficient mismatch repair (dMMR) and BRAFV600E mutation. MMR IHC of formalin-fixed paraffin-embedded tissues from tumor areas obtained from 651 patients with CRC who underwent surgical resection at Hamamatsu University Hospital (Hamamatsu, Japan) between August 2016 and March 2022 were used to evaluate MMR status, which was determined by staining for the expression of 4 MMR proteins (MLH1, MSH2, PMS2, and MSH6).

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Article Synopsis
  • The study investigated how the duration of ulcerative colitis (UC) affects the levels of two biomarkers: fecal calprotectin (FC) and fecal immunochemical occult blood tests (FIT).
  • Researchers analyzed data from 128 colonoscopic exams, categorizing UC cases by disease duration into short (0-5 years), medium (6-13 years), and long-term (14-38 years) groups.
  • Results showed that FC and FIT levels correlated significantly with disease severity scores, but the strength of these correlations was generally lower in long-term UC cases, suggesting that FC is particularly effective in monitoring short-term disease.
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The frequency of deficient mismatch repair (dMMR) or microsatellite instability-high colorectal cancer (CRC) is estimated to be ~15% of all patients with CRC; however, the patients reported are limited to surgical cases, and the frequency of patients exhibiting stage 0 disease is not considered, despite the currently increasing use of endoscopic techniques to cure a number of these patients. In the present study, the DNA MMR status for stage 0 patients with CRC treated using endoscopic submucosal dissection or endoscopic mucosal resection was analyzed via immunohistochemical staining of four types of proteins, namely MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), MSH6 and PMS1 homolog 2 MMR system component, in adenocarcinoma specimens. Notably, none of the endoscopically resected specimens exhibited dMMR among the 41 patients diagnosed with stage 0 CRC.

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A phase II study of second-generation photodynamic therapy (PDT) using talaporfin sodium has shown excellent treatment results for esophageal cancer with local failure after chemoradiotherapy (CRT) or radiotherapy (RT). However, only a few studies have reported this therapy in clinical practice. This study aimed to confirm the efficacy and safety of salvage PDT using talaporfin sodium for esophageal cancer in various clinical situations.

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A 37-year-old woman exhibited abnormal liver enzyme levels without any symptoms at a medical check-up. She was born and raised in Hubei, China, and had immigrated to Japan in her mid-thirties. Ultrasonography revealed an enlarged caudate lobe of the liver and a wide moniliform portal vein, whereas computed tomography revealed lined calcification on the surface of the liver and on the collateral vein of the portal vein.

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Cervical inlet patch (CIP), also referred to as esophageal heterotopic gastric mucosa, is regarded as the residue of columnar epithelium of the embryonic esophagus. Narrow band imaging increases the detection rate of CIP. Herein, we present a 55-year-old man with symptomatic circumferential inlet patch.

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