Distribution of LAT1-targeting PET tracer was independent of the tumor blood flow in rat xenograft models of C6 glioma and MIA PaCa-2.

Objective: L-type amino acid transporter 1 (LAT1) is strongly expressed on the cell membrane in various types of human cancer cells, while being minimally expressed in normal or inflammatory tissues. Therefore, LAT1-targeting PET tracers have been developed for cancer-specific imaging. The purpose of this study was to study the distribution of two LAT1-targeting PET tracers, L-4-borono-2-F-fluoro-phenylalanine (F-FBPA) and L-3-F-alpha-methyl tyrosine (F-FAMT), in relation to the tumor blood flow, using rat xenograft models.

Practical calculation method to estimate the absolute boron concentration in tissues using F-FBPA PET.

Purpose: The purpose of this study was to establish a practical method to estimate the absolute boron concentrations in the tissues based on the standardized uptake values (SUVs) after administration of 4-borono-phenylalanine (BPA) using 4-borono-2-F-fluoro-phenylalanine (F-FBPA) PET.

Methods: Rat xenograft models of C6 glioma (n = 7, body weight 241 ± 28.0 g) were used for the study.

F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with F-FDG and C-Methionine PET.

Purpose: The purpose of this study was to evaluate the usefulness of L-4-borono-2-F-fluoro-phenylalanine (F-FBPA) as a tumor-specific probe, in comparison to F-FDG and C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers.

Methods: Cellular analyses of FBPA were performed to evaluate the transportablity and K value. PET studies were performed in rat xenograft models of C6 glioma (n = 12) and in rat models of turpentine oil-induced subcutaneous inflammation (n = 9).