Cerebral oxygenation in the beach chair position before and during general anesthesia in patients with and without cardiovascular risk factors.

Study Objectives: To evaluate changes in cerebral tissue oxygen index (TOI) values under the beach chair position before and during general anesthesia in surgical patients with or without cardiovascular risk factors.

Design: Prospective study.

Setting: Operating room in the university hospital.

[A case of upper airway obstruction associated with flexed cervical position after posterior occipito-cervical fusion--a retrospective radiographic analysis by the O-C2 angle].

A 71-year-old female developed upper airway obstruction due to flexed cervical position after posterior occipito-cervical fusion. After the operation, she was re-intubated with the air-Q intubating laryngeal airway. Revision surgery allowing the angle to return to the neutral position was performed to attenuate the overflexion of the cervical position.

[Postoperative pain management by continuous intravenous infusion of fentanyl using the single-use continuous infusion device].

Background: Continuous infusion of fentanyl for postoperative pain management is performed commonly. But the usage of traditional syringe pump or infusion pump sometimes makes medical staff confusing for its difficulties of handling. We have simplified the postoperative pain management system using the single-use continuous infusion device and the protocol for administration of fentanyl.

Comparison of bicarbonate and base excess values analyzed by four different blood gas analyzers.

Comparison of the calculation formula, reproducibility, correlation and variation of bicarbonate ion concentration (HCO(3) (-)), and base excess value (BE) among four blood-gas analyzers was performed. No HCO(3) (-) and BE values calculated from the formulas showed any clinically significant difference, and all analyzers showed good correlation on their measurements. On the actual measurement of a specific sample, however, BE values from the same sample ranged between -6.

The effects of sevoflurane and propofol on QT interval and heterologously expressed human ether-a-go-go related gene currents in Xenopus oocytes.

Sevoflurane can induce prolongation of the cardiac QT interval by inhibiting the repolarization phase of the action potential. This may occur as a result of inhibition of the human ether-a-go-go related gene (HERG) channel. To clarify the mechanisms of anesthetics on HERG channels, we monitored the electrocardiogram and measured QT intervals in the guinea pig in the presence of sevoflurane and propofol.

Effects of ropivacaine on membrane potential and voltage-dependent calcium channel current in single guinea-pig ventricular myocytes.

Purpose: This study was undertaken to assess the effects of ropivacaine on the membrane action potential and the voltage-dependent L-type calcium channel current ( I(Ca)) in guinea-pig single ventricular myocytes.

Methods: Single ventricular myocytes were prepared by enzymatic dispersion. Whole-cell current and voltage-clamp techniques were used to monitor membrane potentials and I(Ca).

[Mechanism of QT interval prolongation induced by sevoflurane in guinea-pig ventricular myocyte].

Background: Sevoflurane causes QT interval prolongation clinically, but its precise mechanism has not been clarified. We examined the mechanism of QT interval prolongation induced by sevoflurane by means of electrophysiological technique in guinea-pig ventricular myocyte.

Methods: Electrocardiogram was recorded in guinea-pig and effect of sevoflurane (1, 2, 4%) was examined.