Sugar-carrying Polystyrenes Facilitate Harvesting of APCs from MLRs: Possible Application of Sugar-carrying Polystyrenes to Immunotherapy.

Antigen-presenting cells (APCs) play a pivotal role in cancer immunotherapy. APCs in conventionally used flasks are harvested by enzymatic digestion or cell scraping for application to cancer immunotherapy. However, these methods may impair functional molecules expressed on the APC surface and reduce their effects in cancer immunotherapy.

Human amniotic cell sheet harvest using a novel temperature-responsive culture surface coated with protein-based polymer.

Human amniotic epithelial (hAE) and mesenchymal (hAM) cells are believed to have the potential to differentiate into various functional cells, such as neurons, hepatocytes, cardiomyocytes, and pancreatic beta cells. However, cell transplantation has been performed by injection of cell suspensions, and thus it is difficult to control shape, size, location, and functions of differentiated cells. To overcome these problems, we developed a novel temperature-responsive culture surface coated with elastic protein-based polymer.