Publications by authors named "Masami Kelly"

Objective: To investigate the association between higher injury severity and increased informal caregiving received by injured older adults.

Summary Of Background Data: Injured older adults experience high rates of functional decline and disability after hospitalization. Little is known about the scope of caregiving received post-discharge, particularly from informal caregivers such as family.

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Article Synopsis
  • - The study evaluates the psychometric performance of the NCCN-FACT Ovarian Cancer Symptom Index-18 (NFOSI-18) in patients with advanced ovarian cancer, using observational data from 897 patients undergoing treatment.
  • - It assesses factors like internal consistency reliability and construct validity, finding that the NFOSI-18 scores show acceptable reliability and correlate well with other established quality of life measures.
  • - The results indicate specific clinically important differences associated with various symptoms and treatment effects, which can help in interpreting treatment outcomes in clinical trials.
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Background: During the height of the coronavirus disease 2019 (COVID-19) pandemic, elective surgeries, including oncologic surgeries, were delayed. Little prospective data existed to guide practice, and professional surgical societies issued recommendations grounded mainly in common sense and expert consensus, such as medical therapy for early-stage breast and prostate cancer patients. To understand the patient experience of delay in cancer surgery during the pandemic, we interviewed breast and prostate cancer patients whose surgeries were delayed due to the pandemic.

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Background: Evolving regulatory guidelines recommend routine assessment of the acceptability of pediatric oral medicines throughout clinical development processes. However, such assessment is problematic owing to a lack of standard methods or criteria that define acceptability for children and their caregivers. This research aimed to identify the attributes of acceptability for targeted oral formulation types that are important to children, and to develop content-valid patient- and caregiver-reported outcome acceptability measures for use in the context of clinical drug development.

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Background: Patients treated with peanut oral immunotherapy (OIT) may experience adverse reactions, particularly during up-dosing.

Objective: To develop the Side Effects of Peanut Oral Immunotherapy Diary (SEPOD), an electronic questionnaire assessing the daily side effects of peanut OIT in clinical trials.

Methods: Content and design of the SEPOD were informed by empirical literature review and meetings with 3 allergy-immunology experts.

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Article Synopsis
  • Current r-hGH replacement therapy for growth hormone deficiency (GHD) involves daily subcutaneous injections, which are burdensome for patients and may lead to poor adherence to treatment.
  • To improve treatment compliance and outcomes, qualitative research was conducted to develop the Life Interference Questionnaire for Growth Hormone Deficiency (LIQ-GHD) that captures patient experiences related to these injections.
  • The LIQ-GHD was tested through interviews and a cross-sectional study to assess its content, reliability, and validity across different patient age groups, using expert insights and literature review to refine the questionnaire.
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