Publications by authors named "Masako Tomotsune"
Background: The present study aimed to examine the effect of magnesium (Mg) supplementation on cisplatin-induced nephrotoxicity (CIN) in pediatric cancer patients.
Methods: The present phase-2, open-label, multicenter, randomized controlled trial enrolled patients aged less than 20 years who were scheduled to receive cisplatin-containing chemotherapy and randomly allocated them at a ratio of 1:1 to a Mg supplementation arm with even-numbered chemotherapy courses (arm AB) or another arm with odd-numbered courses (arm BA). Analysis objects were reconstructed into two groups depending on whether the chemotherapy course had Mg supplementation (group B) or not (group A).
Background: The importance of the ratio of creatinine to urinary protein, albumin, and low-molecular weight protein as a urinary marker in chronic kidney disease patients is widely recognized. However, no reference values have hitherto been established for these markers in Japanese children. The present study aimed to establish the reference values for these urinary markers in Japanese children.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on congenital anomalies of the kidney and urinary tract (CAKUT) as a leading cause of chronic kidney disease (CKD) in children, identifying effective urine analysis methods to detect kidney dysfunction.
- Researchers compared the efficacy of urine alpha 1-microglobulin (AMCR) and beta 2-microglobulin (BMCR) ratios against conventional urine dipstick tests and other parameters like protein and albumin-to-creatinine ratios.
- Results showed that AMCR and BMCR are more effective for detecting CAKUT in children with stage 3-4 CKD, with high sensitivity and specificity, but further validation for AMCR is needed. *
Unlabelled: Although cisplatin is one of the most effective agents against various pediatric cancers, it is sometimes difficult to manage due to its dose-limiting nephrotoxicity. Magnesium sulfate (Mg) showed a kidney-protective effect against cisplatin-induced nephrotoxicity (CIN) by regulating renal platinum accumulation both in vitro and in vivo, and the body of clinical data demonstrating the efficacy of this drug in adult cancer patients is increasing.In this open, multicenter, phase-2, randomized trial, patients under age 18 years who are scheduled to receive cisplatin-containing chemotherapy will be enrolled and randomly allocated either to an Mg supplementation arm in even-numbered chemotherapy courses (arm AB) or to another arm in odd-numbered courses (arm BA), with a 1:1 allocation.
View Article and Find Full Text PDFImportance: Few studies with sufficient statistical power have shown the association of the z score of the coronary arterial internal diameter with coronary events (CE) in patients with Kawasaki disease (KD) with coronary artery aneurysms (CAA).
Objective: To clarify the association of the z score with time-dependent CE occurrence in patients with KD with CAA.
Design, Setting, And Participants: This multicenter, collaborative retrospective cohort study of 44 participating institutions included 1006 patients with KD younger than 19 years who received a coronary angiography between 1992 and 2011.