Publications by authors named "Masako Minami"
Eur J Pharmacol
December 2023
Article Synopsis
- Augmenting T-cell activity is key to improving cancer immunotherapy, and inhibiting the HPK1 kinase can boost cancer immunity by enhancing T-cell receptor signaling.
- The study introduces DS21150768, a new small-molecule inhibitor of HPK1 that effectively enhances T-cell function and demonstrates strong anti-tumor effects in various mouse cancer models.
- DS21150768 is orally bioavailable and shows sustained plasma levels, leading to increased immune responses, with promising implications for future HPK1-targeted therapies and understanding tumor characteristics for treatment efficacy.
