Publications by authors named "Masako Hirata"
Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disease that triggers inflammation in various organs due to immune complex buildup and is influenced by type I interferons (IFNs) that indicate disease activity.* -
- Genetic and environmental factors lead to abnormal activation of the immune system, and IFNs play a key role in the disease's development through the Janus kinase-signal transducer and activator of transcription pathway.* -
- Anifrolumab (Saphnelo) is an FDA-approved monoclonal antibody treatment for moderate to severe SLE, given as an intravenous infusion every four weeks, targeting type I interferon receptors to help regulate inflammation.*
In mycoplasmal pneumonia, the bronchi are histopathologically filled with polymorphonuclear leukocytes. The EGFR pathway is involved in IL-8 production. We investigated the contribution of the EGFR pathway to IL-8 production by bronchial epithelial cells (A549) stimulated with Mp-Ag.
View Article and Find Full Text PDFBackground: Treatment with anti-ulcer drugs has been shown to enhance IgE production against food antigens. However, little is known about the immunological effects of cimetidine, a histamine receptor type 2 (H2R) antagonist that is widely used as an anti-ulcer drug, in allergy. Therefore, the present study investigated the role of cimetidine in Th2 immune responses in mice.
View Article and Find Full Text PDF[Pharmacological and clinical profile of rosuvastatin calcium (Crestor)].
Nihon Yakurigaku Zasshi
September 2005
We examined, in rats, the expression of osteocalcin and Jun D in the early stage of reactionary dentin formation after tooth preparation and the accompanying morphological changes. Reverse transcription/polymerase chain reaction analysis revealed strong expression of osteocalcin mRNA in pulp tissue at 2 and 3 days post-preparation compared with that in control teeth. Light microscopy demonstrated that, at the dentin-pulp interface, damaged odontoblasts were detached from the dentin matrix immediately after preparation, with neutrophils lining the dental surface after 1 day.
View Article and Find Full Text PDFA comparison of five techniques for detecting cardiac activity in infants.
Paediatr Anaesth
February 2003
Background: The new guidelines for cardiopulmonary resuscitation recommend that laypersons should begin chest compressions without checking for a pulse because the pulse check has serious limitations in accuracy. We determined the efficacy of the most suitable method to search for cardiac activity in infants.
Methods: Twenty-eight nurses tried to detect infants' cardiac activity and determined their heart rates with five different techniques: palpation of brachial pulse, carotid pulse, femoral pulse, apical impulse and auscultation of apical impulse with the naked ear (direct auscultation technique).