Publications by authors named "Masaki Takikawa"
All-trans retinoic acid (atRA), a metabolite of vitamin A, reduces hepatic lipid accumulation in liver steatosis model animals. Lipophagy, a new lipolysis pathway, degrades a lipid droplet (LD) via autophagy in adipose tissue and the liver. We recently found that atRA induces lipophagy in adipocytes.
View Article and Find Full Text PDFElevated luminal inorganic phosphate suppresses intestinal Zn absorption in 5/6 nephrectomized rats.
Am J Physiol Renal Physiol
March 2024
Article Synopsis
- Zinc is essential for various biological processes, but chronic kidney disease (CKD) often leads to decreased zinc levels (hypozincemia), which can worsen CKD progression.
- In a rat model of CKD, researchers found that while zinc absorption was impaired, a protein involved in zinc transport (ZIP4) was actually upregulated, suggesting other factors were at play.
- They identified elevated phosphate levels as a key inhibitor of zinc absorption, and managing phosphate levels could help improve zinc status in CKD patients.