Publications by authors named "Masaki Michishita"
Article Synopsis
- The study explores the effectiveness of mesenchymal stromal cells (MSCs) in treating inflammatory bowel disease, focusing on the impact of priming these cells with inflamed intestinal tissue versus inflammatory cytokines.
- Researchers used canine adipose-derived MSCs (cADSCs) and compared how priming with colitis tissue affected their ability to inhibit T-cell proliferation, as well as their own growth and survival.
- Results showed that colitis tissue priming improved the therapeutic effect of cADSCs by promoting beneficial immune cell responses and reducing colitis severity, while cytokine priming led to more negative effects on the MSCs.
Article Synopsis
Article Synopsis
- A 9-year-old male Boxer dog was diagnosed with a skin tumor on the jaw that showed aggressive growth and consisted of two types of tumor cells: inner eosinophilic cuboidal cells and outer clear polygonal cells.
- The eosinophilic cells were found to be positive for cytokeratin 8, indicating they were luminal epithelial cells, while the clear cells showed markers typical of myoepithelial cells, such as α-smooth muscle actin.
- The final diagnosis categorized the tumor as an apocrine sweat gland carcinoma-and-malignant myoepithelioma, highlighting the malignant nature of both cell types involved.
Mammary adenocarcinoma, the most common cancer in female dogs, often exhibits the lymph node and lung metastases and has a higher mortality rate. However, mammary adenocarcinoma has no established treatment, except early surgical excision. Canine mammary carcinoma has many common features with human mammary carcinoma, including clinical characteristics, heterogeneity, and genetic aberrations, making it an excellent spontaneous tumor model for human breast cancer.
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- - A 12-year-old male Beagle experienced a month-long decline in appetite and persistent cough, leading to further examination after noticeable weight loss.
- - Imaging revealed widespread issues in the lungs, with sample analysis indicating the presence of a round cell tumor; ultimately, the dog was euthanized due to severe health decline.
- - Post-mortem analysis confirmed a pulmonary solid adenocarcinoma, characterized by abnormal cell growth in the lungs, which exhibited specific immunological markers.