Riles type 1A common carotid artery occlusion diagnosed by specific external carotid artery Doppler waveform pattern in carotid ultrasonography. Case report.

A 67-year-old man was admitted for evaluation of left homonymous hemianopsia. Carotid ultrasonography showed that the right common carotid artery (CCA) was occluded up to just proximal to the carotid bifurcation, and the patent external carotid artery showed retrograde flow to the patent internal carotid artery via the carotid bifurcation. The Doppler waveform pattern of the external carotid artery showed high end-diastolic flow velocity and low pulsatility index.

Percutaneous transluminal angioplasty for stenosis of the posterior cerebral artery in progressive stroke. Case report.

A 59-year-old male presented with repeated transient hemianopsia and hemiparesis on the left. Emergency magnetic resonance angiography showed stenosis of the right posterior cerebral artery (PCA). Endovascular recanalization with percutaneous transluminal angioplasty was performed immediately after the diagnosis.

[Usefulness of the goose neck snare for holding the guiding catheter for carotid artery stenting].

A goose neck snare is a useful device not only for the retrieval of intravascular foreign bodies, such as detachable coils and catheter fragments, but also for holding a guiding catheter. In carotid artery stenting, the guiding catheter should be kept stable in the proximal of the stenotic lesion, but it is sometimes difficult because of the tortuousity of the proximal common carotid artery. We present a case of carotid artery stenting for proximal part common carotid artery stenosis and discuss the usefulness of the goose neck snare from the brachial artery for holding the guiding catheter.

[The surgical treatment of non-functioning pituitary adenomas in the ninth decade].

There are no reports of surgical treatment for non-functioning pituitary adenomas in the 9th decade of life, and it is thought that these patients often select conservative treatment and observation, because of their worry about deterioration of their general condition due to invasive surgery and because hypopituitarism and other medical problems are often present. However, it is also true that there is necessity for considering surgical treatment for the pituitary adenomas even in the 9th decade when there is a complaint of visual disturbance. We carried out the palliative surgical removal of three non-functioning pituitary adenomas with visual disturbance in the 9th decade and report these surgical treatments and outcomes.

[Effectiveness of antiadhesion barriers in preventing adhesion for external decompression and subsequent cranioplasty].

Cranioplasty performed after external decompression for brain swelling due to cerebral infarction, injury and hemorrhage may be difficult because of the development of adhesions between the dura and the temporal muscle, subcutaneous layer. Preventing such adhesions, we have used Seprafilm instead of Gore-Tex membranes which had been used in neurosurgery. Seprafilm were placed between the temporal muscle and the dura with dural plasty using periostium or temporal fascia.

Proximal flow arrest with temporary subclavian steal for internal trapping of a ruptured vertebral artery dissecting aneurysm.

A 48-year-old woman presented with subarachnoid hemorrhage originating from a dissecting aneurysm of the left vertebral artery (VA). Internal trapping with proximal flow arrest was planned. The origin of the left VA was too tortuous to allow positioning of an occlusion balloon catheter and a microcatheter in the left VA via the femoral artery.

[Endovascular treatment for vertebral artery dissecting aneurysm: effectiveness of internal trapping with proximal flow arrest].

Ruptured vertebral artery (VA) dissecting aneurysms are associated with a higher incidence of rebleeding than saccular aneurysms, so, it is encouraged that diagnosis be followed by early treatment. The standard treatment for VA dissecting aneurysms is internal trapping using an endovascular technique. In this procedure, a proximal flow arrest is sometimes used to ensure safety.

[Traumatic panhypopituitarism: case report].

We describe a case of traumatic panhypopituitarism following head injury. Generally considered, posttraumatic hypopituitarism occurs in patients who have suffered from severe head injury. However there were a few case reports of panhypopituitarism due to mild and moderate head injury.

[A spontaneous bilateral subdural effusion in an 11-year-old boy with middle cranial fossa arachnoid cyst].

An 11-year-old boy gradually developed headache, vomiting and diplopia over a period of 1 month. Repeated examinations of head CT scan revealed an arachnoid cyst in the right middle cranial fossa and bilateral subdural effusion of enlarging size. Papilledema was absent on admission, but it became evident after 1 week, and lumbar puncture disclosed very high pressure (800 mmH2O) of the cerebrospinal fluid.

Structural properties of dibenzosuberanylpiperazine derivatives for efficient reversal of chloroquine resistance in Plasmodium chabaudi.

For the purpose of developing chemosensitizers to reverse chloroquine (CQ) resistance in Plasmodium chabaudi in vivo, dibenzosuberanylpiperazine (1-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)piperazine) (DSP) and its piperazin-1-yl derivatives were synthesized systematically. DSP hydrochloride (3) was obtained from the reaction of dibenzosuberanyl chloride with piperazine in the presence of 1,8-diazabicyclo[5,4,0]-7-undecene (DBU). To understand the relationship between the substituent patterns of DSP derivatives and their biological activities, 13 hydroxyalkyl or hydroxyalkenyl derivatives were synthesized by an attack of the piperazine secondary amine of 3 on commercially available epoxides in the presence of triethylamine or DBU, and three alkyl or alkynyl derivatives were synthesized by the reactions of 3 with the corresponding organic chlorides in the presence of DBU.