Publications by authors named "Masakatsu Yamamoto"
Article Synopsis
- The US FDA has mandated the use of the Standard for Exchange of Nonclinical Data (SEND) for pharmaceutical companies developing new drugs in the US market.
- The Japan Pharmaceutical Manufacturers Association (JPMA) initiated a project to analyze SEND datasets specifically for toxicology studies, uncovering variations in how data is populated.
- The Taskforce Team recommends minimizing these variations in both SEND datasets and study protocols to improve data quality, making it easier for regulatory agencies to review and enhancing the overall efficiency of new drug development.
Introduction: We aimed to evaluate the risk factors for mortality and neurodevelopmental impairment (NDI) among infants of 22-23 weeks' gestational age, which currently remain unclear.
Methods: This retrospective case-control study included 104 infants delivered at 22-23 weeks' gestation at Kagoshima City Hospital from 2006 to 2015. We compared 65 and 34 cases of survival to discharge and postnatal in-hospital death (5 excluded), respectively, and 26 and 35 cases with and without NDI, respectively, using maternal, prenatal, and postnatal records.
Background: In Japan, 44.3% of neonates are delivered in private clinics without an attending pediatrician. Obstetricians in the clinics must resuscitate asphyxiated neonates in unstable condition, such as respiratory failure, and they are frequently transferred to tertiary perinatal medical centers.
View Article and Find Full Text PDFBackground: There have been few reports on the outcome of extracorporeal membrane oxygenation (ECMO) in newborn Japanese infants.
Methods: A review was carried out of 61 neonates with ECMO between January 1995 and December 2015 at a single center. ECMO was used in neonates with oxygenation index >20 after conventional treatment.
Previous studies revealed that atropine reduced male fertility in rats without any effects on mating performance, sperm production and motility, and testicular morphology. The present study was conducted to investigate whether the impairment of male fertility induced by atropine was related to the inhibition of sperm and semen transports from the vas deferens and seminal vesicle to the urethra during the process of emission. Male rats were treated with atropine at 125 mg/kg/day for 10-17 days prior to mating with untreated females.
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