Publications by authors named "Masakatsu Fukuzawa"

Background: Map-like redness, pathological intestinal metaplasia, is observed in one-fourth to one-third of patients 1 year after Helicobacter pylori eradication therapy, mainly in the corpus, and is a newly identified endoscopic risk factor for gastric cancer development after eradication. However, it is unclear whether intestinal metaplasia is present before eradication at the site where the map-like redness appears. We aimed to identify endoscopic findings that predict the occurrence of map-like redness before H.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to promote sustainable practices in endoscopy by examining how gowning techniques impact microbial contamination and carbon emissions, assessing the potential for reducing medical waste.* -
  • Involving 25 patients, researchers found a 56% contamination rate across isolation gowns, with higher rates among resident endoscopists compared to experts, particularly noting increased bacteria on the left arm of gowns.* -
  • The bacteria found were non-pathogenic, suggesting that complete changes of protective gear may not be necessary, supporting the initiative for "green endoscopy" to enhance sustainability in medical practices.*
View Article and Find Full Text PDF

Background: This study evaluated the association between the risk factors and prognosis for metachronous esophageal squamous cell carcinoma (ESCC) after endoscopic resection (ER) of esophageal cancer in older patients.

Methods: We conducted a retrospective observational study of 127 patients with ESCC who underwent ER from 2015 to 2020. Patients were classified as non-older (≤ 64 years), early older (65-74 years), and late older (≥ 75 years).

View Article and Find Full Text PDF

Objectives: This study investigated the incidence of lymph node metastasis and long-term outcomes in patients with T1 colorectal cancer where endoscopic submucosal dissection (ESD) resulted in noncurative treatment. It is focused on those with deep submucosal invasion, a factor considered a weak predictor of lymph node metastasis in the absence of other risk factors.

Methods: This nationwide, multicenter, prospective study conducted a post-hoc analysis of 141 patients with T1 colorectal cancer ≥20 mm where ESD of the lesion resulted in noncurative outcomes, characterized by poor differentiation, deep submucosal invasion (≥1000 μm), lymphovascular invasion, high-grade tumor budding, or positive vertical margins.

View Article and Find Full Text PDF

In the present study, the authors examined the association between gastric bacterial infection and gastric endoscopic findings in ()-negative patients. The subjects were 105 -negative patients. The mean age was 72.

View Article and Find Full Text PDF

Background: Map-like redness is a newly identified endoscopic risk factor for gastric cancer in patients who received Helicobacter pylori eradication therapy. However, the incidence rate of map-like redness in patients who received eradication, and the risk factors for the development of map-like redness remain unclear. We hence aimed to investigate the incidence rate of map-like redness at 1-year post H.

View Article and Find Full Text PDF

This case report demonstrates successful treatment outcomes without recurrence using fosfomycin for cellulitis with bacteremia caused by resistant to macrolides, fluoroquinolones, and tetracyclines in agammaglobulinemia and bronchiectasis. Whole-genome sequencing indicated the presence of ST137 harboring and , with mutations in the 23S rRNA and genes.

View Article and Find Full Text PDF

In this study, we investigated the relationship between the cecal intubation time (CIT) and the form and method used for passing through the sigmoid/descending colon junction (SDJ) and the hepatic flexure using an endoscopic position detection unit (UPD), with reference to various factors [age, sex, body mass index (BMI), history of abdominal and pelvic surgery, and diverticulum]. A total of 152 patients underwent colonoscopy with UPD. The mean age was 66.

View Article and Find Full Text PDF

Objective Acute hemorrhagic rectal ulcer (AHRU) is characterized by sudden, painless, and massive bleeding from rectal ulcers. To date, few studies have analyzed the risk factors for AHRU rebleeding. In this study, we clarified the risk factors of rebleeding after initial hemostasis of AHRU through a multicenter study.

View Article and Find Full Text PDF
Article Synopsis
  • Endoscopic resection is a common local treatment for small rectal neuroendocrine tumors, but there's no clear consensus on the best method, prompting a comparison of two techniques: ESD and ESMR-L.
  • The study is a prospective, multicenter, randomized trial involving 266 patients, evaluating the effectiveness of ESMR-L versus ESD, with the main goal of determining if ESMR-L offers similar rates of complete tumor removal (R0 resection).
  • This trial will also assess additional factors like procedure time, costs, and complications, contributing to understanding the best approach for treating these tumors.
View Article and Find Full Text PDF
Article Synopsis
  • The study evaluates the effectiveness of endoscopic submucosal dissection (ESD) as a treatment for local residual or recurrent colorectal tumors, building on previous findings that showed favorable long-term outcomes for large colorectal neoplasms.
  • A multicenter prospective study involved 54 patients with local residual or recurrent tumors, where ESD successfully completed in 98.1% of cases and achieved high rates of en bloc and R0 resections.
  • The results indicated that ESD is a safe and effective option for managing these challenging tumors, with no significant short-term complications and no tumor recurrences during a median follow-up of 60 months.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the link between pharmacokinetic parameters of direct oral anticoagulants (DOACs) and the risk of post-endoscopic submucosal dissection (ESD) bleeding, noting that GI bleeding is a significant concern.
  • It found a 12.8% incidence of post-ESD bleeding in patients on DOACs, with factors such as age and FXa activity correlating significantly with bleeding risk.
  • The research suggests that measuring drug levels and anticoagulant effectiveness could help identify patients at higher risk for bleeding after ESD procedures.
View Article and Find Full Text PDF

Objectives: This study aimed to prevent the infection risk of environmental contamination by feces during endoscopic procedures. We evaluated the effect of coronavirus disease 2019 (COVID-19) on the gastrointestinal tract using fecal polymerase chain reaction (PCR) and examined risk factors affecting endoscopic procedures, to develop infection prevention strategies.

Methods: This single-center prospective observational study enrolled 32 patients diagnosed with COVID-19 at Tokyo Medical University Hospital between January and December 2022.

View Article and Find Full Text PDF
Article Synopsis
  • * Lubiprostone, a chloride channel activator, shows promise for treating chronic constipation, but its long-term efficacy as a standalone therapy in new patients was previously unclear.
  • * A study of 74 patients on lubiprostone revealed that a 24 µg/day starting dose significantly improved chronic constipation for 76.1% of patients over six months, suggesting it reduces the risk of side effects like nausea and diarrhea.
View Article and Find Full Text PDF

Background/aims: Hybrid endoscopic submucosal dissection (ESD), in which an incision is made around a lesion and snaring is performed after submucosal dissection, has some advantages in colorectal surgery, including shorter procedure time and preventing perforation. However, its value for rescue resection in difficult colorectal ESD cases remains unclear. This study evaluated the utility of rescue hybrid ESD (RH-ESD).

View Article and Find Full Text PDF

Background And Aims: Underwater endoscopic submucosal dissection (U-ESD) is a recently developed procedure that has the potential to prevent post-ESD coagulation syndrome (PECS) owing to its heat-sink effect. We aimed to clarify whether U-ESD decreases the incidence of PECS compared with conventional ESD (C-ESD).

Methods: A total of 205 patients who underwent colorectal ESD (C-ESD: 125; U-ESD: 80) were analyzed.

View Article and Find Full Text PDF

We evaluated whether texture and color enhancement imaging (TXI) using a high-definition ultrathin transnasal endoscope (UTE) improves the visibility of early gastric cancer (EGC) compared with white-light imaging (WLI). This study included 31 EGCs observed by TXI mode 2 using a high-definition UTE prior to endoscopic submucosal dissection. The first outcome was to compare the color differences based on Commission Internationale de l'Eclairage L*a*b* color space between EGCs and the surrounding mucosa by WLI and TXI using the UTE (objective appearance of EGC).

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to determine if texture- and color-enhancement imaging (TXI) and narrow-band imaging (NBI) provide better results than white-light imaging (WLI) for diagnosing Barrett’s esophagus.
  • Researchers compared the endoscopic findings and color differences among 40 patients using WLI, TXI, and NBI, finding that NBI showed greater color differences compared to WLI.
  • Despite NBI's advantages in detecting color differences, TXI had a higher visibility score for Barrett's esophagus detection, suggesting both image-enhanced techniques are useful for evaluation compared to WLI alone.
View Article and Find Full Text PDF

Introduction: As the high mortality rate of gastric cancer (GC) is due to delayed diagnosis, early detection is vital for improved patient outcomes. Metabolic deregulation plays an important role in GC. Although various metabolite-level biomarkers for early detection have been assessed, there is still no unified early detection method.

View Article and Find Full Text PDF

Background: The use of an endoscopic position detection unit (UPD) enables better and more objective understanding of the shape and position of the colonoscope. Here, we investigated the reproducibility of the insertion of a colonoscope with UPD.

Materials And Methods: Study participants were 122 patients who received a colonoscopy with UPD twice for the purpose of large bowel screening and surveillance.

View Article and Find Full Text PDF