Investigation of the role of the amino acid residue at position 230 for catalysis in monomeric carbonyl reductase 3.

Monomeric carbonyl reductase 3 (CBR3) is a member of the short-chain dehydrogenase/reductase family. CBR3 exhibits much lower activity than monomeric carbonyl reductase 1 (CBR1) in humans and Chinese hamsters although they are highly homologous to each other in amino acid sequence levels. In the present study, we first cloned the CBR3 gene of rat origin (rCBR3), and characterized its enzymatic activity.

Impact of lymph node metastasis on the pattern of failure and survival in oral carcinomas.

Background: Carcinomas of the oral cavity present a high risk for neck metastases that decrease the disease control and survival.

Methods: A total of 106 patients with squamous cell carcinoma of the oral cavity who had metastatic neck nodes were studied. The impact of neck metastasis and treatment modalities on outcome was assessed.

Squamous cell carcinomas of the mandibular alveolus: analysis of prognostic factors.

Background: To assess the effect of clinicopathologic factors on local tumor control and survival in patients with mandibular alveolar carcinoma.

Methods: Fifty patients with mandibular alveolar carcinoma treated surgically were included in this study. There were 3 patients with T1, 25 with T2, 5 with T3, and 17 with T4 disease.