Publications by authors named "Masahito Masato"
Background/aim: In clinical practice, constipation is one of the most frequent adverse events caused by drugs for overactive bladder (OAB). The occurrence of constipation greatly deteriorates the patient's quality of life. The aim of the study was to evaluate and compare the effects of three commonly used β3 agonists and anticholinergic drugs on the defecation status in patients with OAB.
View Article and Find Full Text PDFBackground/aim: WW and C2 domain-containing 1 (WWC1) protein is a suppressor of malignancies. However, there is no information on the pathological significance of WWC1 in upper urinary tract cancer (UTUC).
Patients And Methods: In this study, WWC1 immunoreactivity was investigated in 152 non-metastatic UTUC samples.
Prostaglandin E2 plays an important role in carcinogenesis and malignant potential of prostate cancer (PC) cells by binding to its specific receptors, E-type prostanoid (EP) receptors. However, anti-carcinogenic effects of the EP receptor antagonist are unclear. In this study, we used a mouse model of PC.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the role of E-type prostanoid receptors (EP1R - 4R) in hormone-sensitive prostate cancer (HSPC) and castration-resistant prostate cancer (CRPC) to understand their impact on cancer aggressiveness.
- - Researchers analyzed tissue samples from 102 HSPC and 27 CRPC patients, focusing on how the expression of these receptors correlates with indicators of tumor growth, cell death, and blood vessel growth.
- - Findings revealed that EP4R is significantly more expressed in CRPC than in HSPC, and its higher levels are associated with increased tumor proliferation, reduced apoptosis, and enhanced growth of blood vessels.
Introduction: Penile fracture is a rare urologic emergency, and its surgical treatment is selected based on the damaged site of the penile corpus cavernosum. Penile fractures at the site of the crus penis are quite rare, and there is controversy regarding the preferred method of surgical repair.
Case Presentation: A 25-year-old Asian man was injured when rolling over in bed.