Publications by authors named "Masahiro Shino"
Article Synopsis
- Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder characterized by the breakdown of red blood cells due to a lack of complement regulators, leading to potentially severe hemolysis, especially during infections and thrombosis.
- A study in Japan reported five COVID-19 patients with PNH who were all vaccinated and treated with different medications for the condition.
- Despite experiencing mild to moderate COVID-19 symptoms and breakthrough hemolysis, none of the patients required oxygen or faced severe complications, and there were no thrombotic issues.
We present a case of a 41-year-old woman who was diagnosed with autoimmune polyendocrine syndrome type 1 (APS-1) at the age of 2. She developed severe anemia and was diagnosed with pure red cell aplasia (PRCA) and T-cell large granular lymphocyte leukemia at the age of 34. The pathogenesis of APS-1 is based on the presence of an inactive mutation in the autoimmune regulator gene on thymic medullary epithelial cells.
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