Publications by authors named "Masahiro Mizutani"

Study Design: A retrospective study.

Objective: To verify the pathophysiology of dysphagia during the acute postoperative phase of anterior cervical surgery and to identify its predictive features, using ultrasonographic (US) examination for upper esophageal sphincter (UES).

Summary Of Background Data: There are no clinical studies investigating dysphagia after anterior cervical surgery, using US examination for UES.

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Background Context: Cervical compressive myelopathy (CCM), caused by cervical spondylosis (cervical spondylotic myelopathy [CSM]) or ossification of the posterior longitudinal ligament (OPLL), is a common neurological disorder in the elderly. For moderate/severe CCM, surgical management has been the first-line therapeutic option. Recently, surgical management is also recommended for mild CCM, and a few studies have reported the surgical outcome for this clinical population.

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Case: A 62-year-old woman who had an unremarkable medical history presented with sudden headache and neck pain. After the presentation, complete quadriplegia and respiratory arrest developed, and the patient was urgently intubated. Magnetic resonance imaging revealed an extensive epidural hematoma (EH), and emergency hematoma evacuation was performed.

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Context: Patients with cervical compressive myelopathy (CCM) often complain of body balance problems, such as fear of falling and bodily unsteadiness. However, no accepted patient-reported outcome measures (PROMs) for this symptomatology exist. The Falls Efficacy Scale-International (FES-I) is one of the most widely used PROMs for evaluating impaired body balance in various clinical fields.

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Background/context: Kyphotic deformity after cervical laminoplasty (CLP) often leads to unfavorable neurological recovery due to insufficient indirect decompression of the spinal cord. Existing literature has described that segmental cervical instability is a contraindication for CLP because it is a potential risk factor for kyphotic changes after surgery; however, this has never been confirmed in any clinical studies.

Purpose: To confirm whether segmental cervical instability was an independent risk factor for postoperative kyphotic change and to examine whether segmental cervical instability led to poor neurological outcomes after CLP for cervical spondylotic myelopathy (CSM).

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Article Synopsis
  • - Antibiotics like cefazolin can cause rare side effects, including neuromuscular blockade (NMB), which leads to paralysis-like symptoms.
  • - NMB is not commonly recognized in neurosurgery and spinal surgery, making it a confusing issue for healthcare providers in those fields.
  • - This report discusses a specific case where a patient experienced periodic quadriplegia after surgery due to NMB from a prophylactic antibiotic, along with a literature review on the topic.
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Objective: C5 palsy (C5P) is a known complication of cervical decompression surgery. The tethering effect of the C5 nerve root following the posterior shift of the spinal cord is the most accepted pathologic mechanism for C5P development; however, this mechanism cannot fully explain C5P by itself in clinical practice. Separately, some studies have suggested that preoperative severe spinal cord compression and postoperative morphological changes in the spinal cord affect C5P development; however, no previous study has quantitatively addressed these possibilities.

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Background: Percutaneous ultrasonography (PUS) is used to evaluate the status of the spinal cord after cervical laminoplasty (CLP). This technique helps assess real-time movements of the spinal cord and provides immediate information regarding the decompression status. Additionally, it can also be utilized to evaluate the status of the spinal cord in various body positions and neck postures.

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Article Synopsis
  • Many neurological disorders can show similar symptoms to degenerative cervical myelopathy (DCM) and myeloradiculopathy (DCMR), making accurate diagnosis challenging.
  • A study of 230 patients revealed that only 3 (1.3%) were diagnosed with coexisting diseases like amyotrophic lateral sclerosis, lung cancer, and polymyalgia rheumatica after cervical surgery, which were initially missed due to symptom overlap.
  • Surgeons need to be aware that coexisting conditions may be overlooked prior to surgery, and if symptoms persist post-surgery, a thorough investigation into other potential diseases is essential.
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Study Design: This was a retrospective study.

Objective: The objective of this study was to investigate the diagnostic utility of percutaneous ultrasonography (PUS) for postoperative epidural hematoma (EH) as a postoperative complication.

Summary Of Background Data: We investigated the usefulness of PUS for determining the need of surgical evacuation of postoperative EH by comparing the postoperative magnetic resonance imaging (MRI) and PUS of the spinal cord.

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Article Synopsis
  • This study aimed to determine if biologic agents (BAs) help maintain the size of a critical C-2 pedicle screw trajectory in patients with rheumatoid arthritis (RA).
  • It analyzed CT images from 100 RA patients, comparing those treated with BAs to those who were not, and found that BAs allowed for a larger screw diameter and less joint damage.
  • The findings suggest that early treatment with BAs is crucial to preserve the C-2 pedicle's size, which is vital for effective surgical stabilization of the cervical spine in RA patients.
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Musculoskeletal injuries are a common occurrence in military service members. It is believed that the load carried by the service member impedes stability and alters back and pelvis kinematics, increasing their susceptibility to musculoskeletal injuries, specifically in the lower extremities. The purpose of this study was to examine the effects of two different loads on postural sway, forward trunk lean, and pelvic girdle motion in United States Army Cadets.

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Article Synopsis
  • The study aimed to assess how age and baseline characteristics influenced the effects of pravastatin treatment on cardiovascular disease (CVD) risk among Japanese patients with mild to moderate hyperlipidemia.
  • Researchers analyzed 7,832 participants divided into six age groups and found that older men had higher rates of diabetes and hypertension, while younger men had more smoking and obesity.
  • Pravastatin treatment showed a 30-40% reduction in CVD risk for all age groups, with older women experiencing a particularly significant decrease in risk compared to younger women.
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The purpose of this study is to develop a new endoscope for performing simple surgical tasks inside a cardiac atrium/chamber filled with blood, i.e., for performing "off-pump" cardiac surgeries.

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We investigated a nodulin 26-like protein NIP2;1, which belongs to the third subgroup of Arabidopsis aquaporins. Histochemical analysis of a promoter-beta-glucuronidase fusion revealed the root-specific expression of NIP2;1. The NIP2;1 protein was detected in young roots, but not in leaves, stems, flowers or siliques.

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Aquaporins mediate the movement of water across biomembranes. Arabidopsis thaliana contains 35 aquaporins that belong to four subfamilies (PIP, TIP, SIP, and NIP). We investigated their expression profiles immunochemically in suspension-cultured Arabidopsis thaliana cells during growth and in response to salt and osmotic stresses.

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We examined whether vanillin (VA) and CoCl ∙6H O(CoCl ), antimutagens, which have mutation suppressing effect, i.e., promotion of cellular repair function in vitro, can modify the teratogenicity in mice caused by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a direct-acting monofunctional alkylating agent.

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