Publications by authors named "Masahiro Kanayama"

Article Synopsis
  • A study was conducted to explore the link between obesity and the progression of OPLL (heterotopic ossification of the posterior longitudinal ligament of the spine) in Asian patients, focusing on how fat-related biochemical signals, or adipokines, might impact this condition.
  • Researchers compared adipokine levels, including leptin and adiponectin, between patients with different degrees of OPLL severity and healthy controls to see if these factors correlate with disease progression.
  • Findings revealed that patients with more severe OPLL had a higher BMI, lower adiponectin/leptin ratios, and elevated osteocalcin, suggesting a potential relationship between obesity, adipokine dysregulation, and the severity of OPLL.*
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Objective: This study aimed to evaluate preoperative and perioperative predictors associated with persistent low back pain (LBP) following lumbar fusion in patients aged >75 years.

Methods: This single-center retrospective study examined 310 patients aged >75 years who underwent lumbar fusion for lumbar degenerative disease (104 males, 206 females; mean age, 79 [75-90] years). The visual analog scale (VAS) score for LBP was examined preoperatively and 2-year postoperatively.

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Patients with congenital absence of a lumbar pedicle and nerve root anomaly presenting with ipsilateral foraminal stenosis are extremely rare. An 80-year-old man had low back and right thigh pain. Radiographs and computed tomography (CT) showed L3 vertebral body fracture and the absence of the right L3 lumbar pedicle.

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Objective: To evaluate the preoperative and perioperative predictors of persistent leg numbness following lumbar fusion in patients aged ≥ 75 years.

Methods: This single-center retrospective study examined 304 patients aged ≥ 75 years who underwent lumbar fusion for lumbar degenerative disease (102 men, 202 women; mean age, 79.2 [75-90] years).

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Introduction: Systemic osteogenesis has been speculated to be involved in the pathogenesis of ossification of the posterior longitudinal ligament (OPLL). Our purpose was to compare the radiologic prevalence and severity of heterotopic ossification in foot tendons of Japanese patients with OPLL and to determine their association with systemic heterotopic ossification.

Materials And Methods: Clinical and radiographic data of 114 patients with OPLL were collected from 2020 to 2022.

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Introduction: We aimed to investigate the effects of zinc deficiency and zinc medication in osteoporosis patients undergoing denosumab (DMAb).

Materials And Methods: This retrospective study was conducted at a single hospital. The participants were female osteoporosis patients visiting between April 2019 and April 2020.

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Background: Measurement of trunk muscle cross-sectional area (CSA) using axial magnetic resonance imaging (MRI) is considered clinically meaningful for understanding several spinal pathologies, such as low back pain and spinal sagittal imbalance. However, it remains unclear whether trunk muscle mass (TMM) measured using dual-energy X-ray absorptiometry (DXA) can predict the trunk muscle CSA. The aim of this study is to determine if DXA-derived TMM is associated and predicts with CSA of paraspinal muscles and gluteus maximus measured using MRI in healthy volunteers.

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Background: This study aims to investigate the effect of pre-operative hemoglobin A1c (HbA1c) and pre-operative blood glucose control on the rate of surgical site infection (SSI) after posterior lumbar instrumentation surgery in diabetes mellitus (DM) patients.

Methods: A total of 1046 patients who had undergone posterior lumbar instrumentation surgery were reviewed. Based on pre-operative HbA1c, patients were divided into three groups: non-DM group, low HbA1c group (HbA1c < 7.

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Background: The choice of operative method for lumbar spinal stenosis with Meyerding grade I degenerative spondylolisthesis remains controversial. The purpose of this study was to identify the preoperative factors affecting the 2-year postoperative patient-reported outcome in Meyerding grade I degenerative spondylolisthesis.

Methods: Seventy-two consecutive patients who had minimally invasive decompression alone (D group; 28) or with fusion (DF group; 44) were enrolled.

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Background: There are few studies about sexual function in the patient with posterior lumbar spinal fusion for degenerative lumbar disease. The aim of this study is to investigate sexual activities in patients with lumbar degenerative disease before and after lumbar fusion surgery.

Methods: We recruited 35 patients who underwent lumbar spinal fusion at the age of 55 years or younger.

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Background: Under the restriction of social activities during the coronavirus disease 2019 (COVID-19) pandemic, there was concern about the loss of muscle mass due to a decrease in physical activity for the elderly. The purpose of this study was to investigate the characteristics of older patients with postmenopausal osteoporosis who developed loss of muscle mass during the COVID-19 pandemic in Japan.

Methods: A total of 54 patients with postmenopausal osteoporosis were evaluated in this study.

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Article Synopsis
  • Ossification of the posterior longitudinal ligament of the spine (OPLL) is a disease that can cause serious neurological issues, and its causes are not fully understood, particularly in relation to type 2 diabetes and high body mass index (BMI).
  • A comprehensive meta-analysis involving 22,016 Japanese individuals identified 14 significant genetic markers linked to OPLL, with 8 being newly discovered, and further analyses pointed to specific genes associated with the disease.
  • The research revealed that increased BMI and high bone mineral density could have a causal relationship with OPLL, and different subtypes of the disease were identified, particularly highlighting a strong correlation between BMI and thoracic OPLL.
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Article Synopsis
  • The study investigates the link between dyslipidemia (abnormal lipid levels) and symptomatic ossification of the posterior longitudinal ligament (OPLL) in Japanese patients.
  • Data from 92 OPLL patients and 246 control participants were analyzed, revealing that dyslipidemia was significantly more common in those with OPLL.
  • The findings suggest that dyslipidemia, along with factors like age, body mass index (BMI), and diabetes, may contribute to the development of OPLL.
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Objective: Although the number of elderly patients requiring lumbar fusion for lumbar degenerative disorders has increased over time, the postoperative outcomes of lumbar fusion in very elderly patients (> 85 years) remains unknown. This study aimed to evaluate the comprehensive outcomes of lumbar fusion in elderly patients older than 85 years with mid-term follow-up.

Methods: The authors retrospectively researched patients older than 85 years who underwent single- or double-level posterior lumbar interbody fusion or transforaminal lumbar interbody fusion from 2012 to 2019.

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Background: This study compared the re-revision rate and radiographic outcomes of revision total hip arthroplasty (THA) using a Kerboull-type acetabular reinforcement device (KT plate) with bulk structural allograft and metal mesh with impaction bone grafting (IBG).

Methods: Ninety-one hips of 81 patients underwent revision THA for American Academy of Orthopedic Surgeons (AAOS) classification type III defects from 2008 to 2018. Of these, seven hips of five patients and 15 hips of 13 patients were excluded due to insufficient follow-up information (< 24 months) and large bone defects with a vertical defect height ≥ 60 mm, respectively.

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Study Design: Retrospective investigation using a prospectively collected database.

Objective: To examine the appearance and characteristics of vertebral bone marrow edema (BME) in the normal healing of lumbar interbody fusion.

Summary Of Background Data: Although BME in pathological spinal conditions has been well-documented, the patterns and characteristics of BME in the normal healing process of spinal fusion remains unexplored.

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Objective: Symptomatic postoperative lumbar epidural hematoma (PLEH) may lead to poor outcomes even after evacuation. This study aimed to verify the short-term clinical outcomes after the evacuation of PLEH and to clarify the characteristics of the patients with poor postoperative outcomes.

Methods: Twenty-five patients (average age; 70.

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Introduction: Despite perioperative risks in nonagenarian patients who undergo open spine surgery for degeneration disorder or spinal trauma being of great interest, the prevalence of complications in this group remains unclear. This study aims to examine the perioperative complications of open spine surgery in the elderly over 90 years of age.

Methods: Preoperative and intraoperative characteristics including the American Society of Anesthesiologists Physical Status (ASA-PS) class, type of surgery, and complications within 30 postoperative days were retrospectively collected from the medical records of nonagenarians who underwent open spine surgery between April 2004 and July 2019 at our spine centers.

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Introduction: A 28.2 μg twice-weekly formulation of teriparatide (2/W-TPD) was developed to provide comparably high efficacy for osteoporosis to a 56.5 μg once-weekly formulation while improving the safety and persistence rate.

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Introduction: In the early phase of the coronavirus disease 2019 (COVID-19) pandemic, the importance of triaging surgeries was suggested to reduce burdens on the existing health system and maintaining service. The governor declared a state of emergency and requested that residents avoid going out unnecessarily (semi-lockdown) for the entire prefecture including our medical region from February 28 until May 25, 2020. However, for several spine patients, a significant delay in care may result in the progression of extremity weakness and pain.

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Background: The aim of this study was to investigate whether or not pre-existing asymptomatic neuroforaminal stenosis adjacent to the fusion level develops adjacent segment disease (ASD) after single-level lumbar interbody fusion.

Summary And Background Data: Risk factors of ASD after spinal fusion have been well investigated, but there have been few studies focused on the relationship between ASD and pre-existing asymptomatic neuroforaminal stenosis.

Methods: A total of 302 patients who had undergone a single-level lumbar interbody fusion were reviewed at a minimum of 2 year follow-up.

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Article Synopsis
  • The study investigates the progression of ossification of the posterior longitudinal ligament (OPLL) in the thoracic spine compared to the cervical spine using whole-spine CT scans from 123 patients.
  • It identifies that younger age is a common risk factor for OPLL progression for both cervical and thoracic cases, with additional independent risk factors found specifically for thoracic OPLL such as high BMI and male sex.
  • The results suggest that patients with thoracic OPLL experience more widespread progression across the spine than those with cervical OPLL.
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Study Design: Retrospective case-control study.

Objective: This study aimed to identify the underlying pathologies of non-rheumatic retro-odontoid pseudotumors (NRPs), which would help establish an appropriate surgical strategy for myelopathy caused by NRP.

Methods: We identified 35 patients with myelopathy caused by NRP who underwent surgery between 2006 and 2017.

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Introduction: Osteoplastic hemilaminectomy for the treatment of lumbar foraminal nerve root compression is a safe technique as the exiting nerve root can be directly observed during neuroforaminal decompression without spinal fusion. Moreover, this procedure allows anatomical reconstruction of the posterior elements. However, there might be a potential risk for the progression of lumbar segmental instability after performing this procedure.

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