Publications by authors named "Masahiro Ishima"
Article Synopsis
- Hypoxic zones in tumors make them resistant to radiation therapy, but drugs that improve oxygen levels, like SQAP, can enhance treatment effectiveness.
- The study used various imaging techniques to show how SQAP affects oxygen levels and blood flow in tumors before radiation.
- Results indicated that SQAP improves tumor oxygenation and blood perfusion, leading to better responses to radiation therapy and potentially delaying tumor growth.
Article Synopsis
- SQAP is a new strong radiosensitizer that helps inhibit blood vessel formation in tumors, leading to better oxygen levels and smaller tumor sizes.
- In a study with mice that had human lung cancer, researchers tracked how SQAP was distributed, broken down, and expelled from the body after injection.
- Results showed that while SQAP spread quickly throughout the body and decreased rapidly, it remained longer in tumor tissues compared to other organs, although radioactivity from SQAP disappeared entirely by 72 hours.
J Am Chem Soc
December 2013
Article Synopsis
- - The study describes the first successful total synthesis of MA026, a unique lipocyclodepsipeptide found in Pseudomonas sp. RtIB026, and identifies its potential target protein for combating hepatitis C virus (HCV).
- - MA026 is composed of a cyclodepsipeptide, chain peptide, and N-terminal (R)-3-hydroxydecanoic acid, with its synthesis involving intricate steps like calorie coupling and macrocyclization to create its active form.
- - Testing in HCV cell cultures shows that MA026 effectively reduces HCV infection by interfering with the virus's entry into liver cells, and further analysis identified claudin-1 as its specific target.
Anticancer Res
November 2010
Article Synopsis
- The study aimed to investigate how a specific lipid (α-SQMG) combined with X-irradiation affects tumor microenvironments in colon cancer cells.
- Using a human colon cancer cell line in mice, researchers monitored tumor growth and analyzed changes in microenvironment characteristics related to blood vessel formation and oxygen levels.
- Results showed that the combination treatment improved the effectiveness of radiation therapy, leading to significant changes in tumor vessels and their structures, potentially enhancing the response to further radiation.
