Publications by authors named "Masahiko Okano"
Synthesis and structure-activity relationship studies of a series of 4-aminoquinazoline derivatives led to the identification of (1R,2S)-17, N-[(1R,2S)-2-({2-[(4-chlorophenyl)carbonyl]amino-6-methylquinazolin-4-yl}amino)cyclohexyl]guanidine dihydrochloride, as a highly potent ORL1 antagonist with up to 3000-fold selectivity over the mu, delta, and kappa opioid receptors. Molecular modeling clarified the structural factors contributing to the high affinity and selectivity of (1R,2S)-17.
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- The text discusses a case of a 69-year-old woman who developed esophageal candidiasis after using inhaled steroids daily for her chronic allergic rhinitis.
- After experiencing difficulty swallowing, an endoscopy revealed both pharyngitis and esophageal candidiasis, leading to a cessation of the steroid and treatment with Azunol mouthwash.
- Follow-up examinations showed significant improvement in her condition and no further symptoms, suggesting that the esophageal candidiasis was linked to the inhalation steroid use.
Article Synopsis
- Gastrointestinal endoscopy revealed high-grade esophageal candidiasis in two bronchial asthma patients using inhaled corticosteroids, specifically fluticasone propionate (FP).
- Out of 20 long-term FP users, 35% showed signs of esophageal candidiasis, a rate higher than usual, suggesting that inhaled corticosteroids may linger in the esophagus and contribute to this condition.
- Adjusting the timing of FP inhalation improved one patient's candidiasis grade, indicating that avoiding immediate sleep after inhalation can help reduce esophageal irritation.