Publications by authors named "Masahide Anada"
Cytokeratin-positive interstitial reticulum cell (CIRC) tumor is an extremely rare malignant neoplasm and a subtype of fibroblastic reticular cell tumor, classified within the dendritic cell tumor group. We describe a case of an epicardial CIRC tumor that was resected and subsequently recurred in the left pulmonary hilum. This recurrence was treated with immunotherapy followed by radiotherapy.
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- The study aimed to assess dosimetric differences in nodal clinical target volume (CTV) for locally advanced non-small cell lung cancer (NSCLC) by comparing geometric expansion and lymph node (LN) station-based approaches based on European guidelines.
- Results showed that the geometric expansion method resulted in significantly lower doses and volumes of radiation affecting the esophagus, lungs, and heart compared to the LN station approach.
- Additionally, patients with LN metastases in certain stations experienced more significant differences in lung volume radiation exposure when using geometric expansion, suggesting it may be a better option for reducing radiation dose.
Background/aim: We evaluated the treatment outcomes of intensity-modulated radiation therapy (IMRT) using a standard radiation dose in patients with high-grade glioma (HGG).
Patients And Methods: We conducted a prospective, single-institutional, single-arm trial. Patients aged 20-75 years with histologically proven HGG were enrolled.
Background/aim: We compared three-dimensional conformal radiotherapy (3D-CRT) with intensity-modulated radiotherapy (IMRT) for avoiding dosimetric risk factors related to pulmonary complications after neoadjuvant chemoradiotherapy followed by surgery (NACRT-S) for non-small cell lung cancer (NSCLC).
Patients And Methods: We performed simulations in 11 patients with dosimetric risk factors during their treatment with NACRT-S for NSCLC. Radiation treatment plans were generated using 3D-CRT and IMRT to avoid dosimetric risk factors.
Purpose: To retrospectively review locally advanced cervical cancer (CC) cases treated with three-dimensional image-guided brachytherapy (3D-IGBT) and two-dimensional (2D)-IGBT.
Materials And Methods: Patients with Stage IB-IVa CC who underwent intracavitary irradiation between 2007 and 2021 were divided into the 3D-IGBT and 2D-IGBT groups. Local control (LC), distant metastasis-free survival (DMFS), progression-free survival (PFS), overall survival (OS), and gastrointestinal toxicity (G3 or more) were investigated at 2/3 years post-treatment.
Background/aim: We conducted a prospective exploratory study to investigate the relationship between radiation pneumonitis (RP) and transforming growth factor-β1 (TGF-β1) in exhaled breath condensate (EBC).
Patients And Methods: The inclusion criteria were: patients who 1) received thoracic radiotherapy (RT) for lung cancer, 2) were aged ≥20 years, and 3) provided written informed consent. EBC was collected before and 1 month after RT.
Objectives: We evaluated retrospectively the daily target coverage using cone-beam computed tomography (CBCT) in breath-hold image-guided radiotherapy (BH-IGRT) for gastric lymphoma.
Methods: BH-IGRT was performed using a prescribed dose of 30.6 Gy in 17 fractions for the whole stomach.
The purpose of the present retrospective study was to evaluate the feasibility of hippocampal dose-volume parameters associated with memory decline for intensity-modulated radiotherapy (IMRT). In total, 18 patients who underwent IMRT for supratentorial tumors were analyzed. Prescribed doses of IMRT in 30 fractions were 60 Gy to planning target volume (PTV) 1 of the local area and 48-51 Gy to PTV2 of the extended local area.
View Article and Find Full Text PDFBackground/aim: We retrospectively investigated the relationship between pathological complete response (pCR) and tumor volume (TV) reduction during neoadjuvant chemoradiation therapy (NACRT) in non-small cell lung cancer (NSCLC).
Patients And Methods: We evaluated patients who received NACRT (50 Gy/25 fractions with platinum-doublet) plus surgery for NSCLC. TVs before and during NACRT (TV and TV, respectively) were measured based on the sums of the volumes of primary tumors and clinically positive lymph nodes.
Background/aim: We retrospectively compared stereotactic body radiotherapy (SBRT) with conventionally fractionated radiotherapy (CFRT) for a solitary lung tumor after resection of a non-small cell lung cancer (NSCLC), due to a lack of data concerning whether SBRT or CFRT is more effective in this setting.
Patients And Methods: SBRT using 48 Gy in 4 fractions was administered to 15 patients with a peripheral tumor (SBRT group). CFRT using 66-70 Gy in 33-35 fractions was administered to 11 patients with a central tumor (CFRT group).
Article Synopsis
- The American Society of Clinical Oncology states that while systemic therapy is standard for stage IV non-small cell lung cancer (NSCLC), there is currently no cure for this condition.
- A report highlights a case of a 61-year-old woman with stage IV adenocarcinoma who achieved long-term disease-free survival after receiving concurrent chemoradiotherapy (CRT) and subsequent adjuvant chemotherapy.
- The patient's successful treatment suggests the need to investigate specific subgroups of stage IV NSCLC patients to further improve long-term survival outcomes after definitive CRT.
Purpose: We assessed differences in gross tumor volumes (GTVs) for pancreatic cancer between respiratory-ungated positron emission tomography (3D-PET) and contrast-enhanced four-dimensional computed tomography (CE-4DCT).
Materials And Methods: We evaluated the GTVs in 21 patients. The sum of the GTVs, which was individually delineated by observers 1 and 2 on the CE-4DCT images from all respiratory phases, was used as GTV-4DCT.
Background And Purpose: Data regarding respiratory motion of lymph node (LN) stations in pancreatic cancer is limited. Therefore, we assessed their respiratory motion using contrast-enhanced four-dimensional-computed tomography (CE-4DCT).
Material And Methods: We evaluated respiratory motion in 18 pancreatic cancer patients.
Solid-state photochromism of benzopyrans and naphthopyrans (chromenes) was investigated in the temperature range between 300 and 80 K. Variable-temperature diffuse reflectance spectroscopy of microcrystalline powders showed that the extent of photocoloration was greatly enhanced at low temperatures. All the chromenes examined exhibited solid-state photochromism at low temperatures, even when they showed little or no photocoloration at room temperature.
View Article and Find Full Text PDFEnzymatic cyclization of geranylgeranyl diphosphate to fusicoccadiene involves a transannular proton transfer process. Label distribution in the cyclized products derived from deuterium-labeled GGDPs showed that a proton generated from C-10 migrates to C-6 in the intermediary dolabellane framework prior to the second ring formation. Although a direct 1,5-proton transfer would achieve this process, semiempirical MO calculations suggested an alternative pathway, which involves successive 1,4- and 1,5-proton transfers using C-2 as a springboard.
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