Correction: Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.

[This corrects the article DOI: 10.18632/oncotarget.25308.

Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.

Integration of Hepatitis B virus (HBV) into the human genome can cause genetic instability, leading to selective advantages for HBV-induced liver cancer. Despite the large number of studies for HBV integration into liver cancer, little is known about the mechanism of initial HBV integration events owing to the limitations of materials and detection methods. We conducted an HBV sequence capture, followed by ultra-deep sequencing, to screen for HBV integrations in 111 liver samples from human-hepatocyte chimeric mice with HBV infection and human clinical samples containing 42 paired samples from non-tumorous and tumorous liver tissues.