Publications by authors named "Masae Koizumi"
Article Synopsis
- This study introduces a new sperm retrieval technique called micromapping testicular sperm extraction (MMTSE) for treating nonobstructive azoospermia (NOA), aimed at providing a less invasive and more effective approach than traditional microscopic testicular sperm extraction (mTESE).
- MMTSE involves dividing the testis into four sections and making small needle holes to extract tubules, while allowing for real-time assessment of tissue for sperm presence.
- Results showed that all 15 patients in the sperm-positive group retrieved sperm successfully, while only 4 out of 25 in the sperm-negative group were successful with mTESE, highlighting MMTSE's potential benefits.
Purpose: To investigate whether progestin-primed ovarian stimulation (PPOS) with chlormadinone acetate (CMA) adversely affects clinical results and neonatal outcomes, or causes congenital deformities.
Methods: This retrospective study was conducted at private IVF clinic from November 2018 to November 2021. Women underwent oocyte retrieval using gonadotropin-releasing hormone (GnRH) antagonist protocol ( = 835) or PPOS protocol ( = 57) were included.
Purpose: To find the best methods to achieve the highest pregnancy and birth rates for couples needing testicular sperm extraction (TESE)-intracytoplasmic sperm injection (ICSI).
Methods: Retrospectively studied were 801 patients with male factor infertility who had undergone TESE-ICSI between April, 1996 and July, 2016 and who had been categorized into four groups: obstructive azoospermia (OA); non-obstructive azoospermia (NOA); Klinefelter syndrome (KS); and cryptozoospermia (Crypt). The sperm retrieval rate, hormone levels, fertilization rate (FR), pregnancy rate (PR), and birth rate (BR) after ICSI among three groups were compared: fresh testicular sperm (FS)-fresh oocytes (FO) (Group I); frozen-thawed testicular sperm-FO (Group II); and FS-vitrified-warmed oocytes (Group III).
Aim: This study aimed to assess the efficacy of the endometrial receptivity array (ERA) as a diagnostic tool and the impact of personalized embryo transfer (pET) for the treatment of patients with recurrent implantation failure (RIF) in Japan.
Methods: Fifty patients with a history of RIF with frozen-thawed blastocyst transfers were recruited from July, 2015 to April, 2016. Endometrial sampling for the ERA and histological dating and a pET according to the ERA were performed.
Article Synopsis
- Several techniques exist for treating high-grade cervical intraepithelial neoplasia (HG-CIN) in fertile women, each with potential complications such as cervical stenosis, canal shortening, and risks during childbirth.
- The study investigated the safety and efficacy of a new treatment method, the AMTC400 device, on four premenopausal patients with CIN3 and high-risk HPV, which was performed without anesthesia and resulted in minor complications like pain and bleeding.
- After treatment, 50% of the patients tested negative for high-risk HPV, and while initial analysis showed no intraepithelial lesions, histology revealed CIN1 and koilocytosis, indicating moderate treatment effectiveness.
Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is a type of membrane receptor with a seven-transmembrane structure. LGR4 is homologous to gonadotropin receptors, such as follicle-stimulating hormone receptor (Fshr) and luteinizing hormone/choriogonadotropin receptor (Lhcgr). Recently, it has been reported that Lgr4 is a membrane receptor for R-spondin ligands, which mediate Wnt/beta-catenin signaling.
View Article and Find Full Text PDFLgr4 is required for endometrial receptivity acquired through ovarian hormone signaling.
Biosci Biotechnol Biochem
August 2015
Previously, using the Keratin5-Cre transgenic mouse model we reported that female Lgr4-conditional KO mice (Lgr4(K5 KO)) showed subfertility with defective stromal decidualization due to abnormal development of the uterine gland. However, the impact of the LGR4 defect on luminal epithelial cells was not investigated in the previous report. Here, we focused on the receptive state of the luminal epithelium in Lgr4(K5 KO) mice that received ovarian hormone treatment.
View Article and Find Full Text PDFThe present study aimed to evaluate the efficacy and toxicities of nadaplatin-based concurrent chemoradiotherapy (CCRT) in patients with stage IIA to IVA cervical carcinoma. Patients with an International Federation of Gynecology and Obstetrics (FIGO) stage IIA to IVA cervical carcinoma were treated with nadaplatin-based CCRT, using high-dose rate intracavitary brachytherapy (HDR-ICBT) or radiotherapy (RT) alone, in patients with FIGO stage IIA to IVA cervical carcinoma. CCRT with nedaplatin (80 mg/m) was administered on Days 1 and 29.
View Article and Find Full Text PDF