Publications by authors named "Masaaki Yanishi"

Objective: We analyzed robotic partial nephrectomy (RPN) outcomes in obese patients based on body mass index (BMI) and trifecta achievement.

Methods: We retrospectively reviewed 296 patients who underwent RPN at Kansai Medical University Hospital between 2014 and 2022. The preoperative clinical data and perioperative outcomes were evaluated.

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Purpose: To compare the diagnostic performance of photodynamic diagnosis (PDD) enhanced with oral 5-aminolaevulinic acid between the suspected upper tract urothelial carcinoma (UTUC) and bladder urothelial carcinoma (BUC) cases.

Methods: This retrospective study included 18 patients with suspected UTUC who underwent ureteroscopy (URS) with oral 5-ALA in the PDD-URS cohort between June 2018 and January 2019; and 110 patients with suspected BUC who underwent transurethral resection of bladder tumour (TURBT) in the PDD-TURBT cohort between January 2019 and March 2023. Sixty-three and 708 biopsy samples were collected during diagnostic URS and TURBT, respectively.

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Background: Although cisplatin-based chemotherapy is a standard treatment for urothelial carcinoma, it often causes acute kidney injury (AKI). AKI and dysfunction are observed in 25-35% of cisplatin-based chemotherapy patients, who may require treatment down-titration or withdrawal. In this study, we evaluated whether urinary L-FABP is a marker for early diagnosis of cisplatin-caused AKI.

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There are several nephrometry scoring systems for predicting surgical complexity and potential perioperative morbidity. The R.E.

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Article Synopsis
  • Sarcopenia, or decreased muscle mass, is a significant issue for kidney transplant recipients, and myokines like BDNF and myostatin play a role in regulating muscle health.
  • A study involving 40 kidney transplant patients found lower serum BDNF levels in those with low muscle mass and higher myostatin levels in the same group, indicating a potential link between these myokines and skeletal muscle mass.
  • The findings suggest that BDNF and myostatin could serve as useful biomarkers for identifying reduced muscle mass in kidney transplant patients.
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Background: Chronic kidney disease (CKD) involves many factors that can cause frailty and oral hypofunction. We aimed to investigate the prevalence of frailty and oral hypofunction and to examine the associations among kidney function, frailty, and oral function in adults with CKD in Japan.

Methods: This cross-sectional study was conducted at two institutions.

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A 71-year-old man with gross hematuria and urinary retention showed a 7×8 cm polycystic mass compressing the prostate on the right ventral side on pelvic magnetic resonance imaging (MRI). The prostate specific antigen (PSA) level was 6.47 ng/ml.

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Background: The host-related risk factors for surgical difficulty of partial nephrectomy include the presence of thick and adherent adipose tissue surrounding the kidney (adherent perinephric fat [APF]). The kidney and perirenal fat must be isolated in donor nephrectomy. Thus, APF is an important surgery-related factor.

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  • A study assessed the role of preoperative pyuria as a predictor of intravesical recurrence (IVR) in upper urinary tract urothelial carcinoma (UTUC) patients post radical nephroureterectomy (RNU).
  • Researchers analyzed data from 268 UTUC patients to find that those with pyuria had a higher rate of IVR compared to those without.
  • Key findings indicated that preoperative pyuria, ureteral tumor sites, and positive surgical margins significantly increased the risk of IVR, suggesting the need for further validation in clinical settings.
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Purpose: Laparoendoscopic single-site donor nephrectomy (LESSDN) is a feasible and effective procedure because of its non-invasiveness and better cosmetic outcomes. However, there have been few multi-institutional studies conducted by multiple surgeons on LESSDN. We retrospectively compared the clinical data and outcomes between LESSDN and conventional laparoscopic donor nephrectomy (LDN) at multiple institutes in Japan.

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  • Urachal remnants are uncommon and typically found in younger patients, making them suitable for laparoscopic surgery, specifically laparoendoscopic single-site surgery (LESS), which offers good cosmetic results.* -
  • A study analyzed 30 patients who underwent LESS for urachal remnants from 2011 to 2017, noting a mean operative time of 151 minutes, minimal blood loss, and a short hospital stay averaging 5.5 days.* -
  • The findings suggest that LESS is an effective option for treating urachal remnants with less postoperative pain, but more data on safety and aesthetic outcomes is necessary to fully establish this technique.*
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Introduction: Measuring muscle mass is an important step in detecting sarcopenia. The evaluation of sarcopenia is also important for kidney transplant recipients. Methods for estimating muscle mass have been established using computed tomography or magnetic resonance imaging, which are considered the gold standards.

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We report a patient with seminoma which recurred as late relapse at the pelvis with elevated alphafetoprotein (AFP) levels. A 40-year-old man presented with a left testicular tumor and subsequently underwent high orchiectomy in 2006. Pathological findings showed that the tumor was a seminoma with invasion into the tunica albuginea (pT2N0M0).

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  • The study aimed to find predictors of urinary incontinence after robot-assisted laparoscopic radical prostatectomy (RALP), focusing on features seen in postoperative cystography.* -
  • Researchers analyzed data from 150 patients, looking at the bladder's shape and position, assessing continence status through a 1-hour pad test and safety pad use over the following year.* -
  • Results indicated that a narrow vesical angle on cystography is a significant predictor of urinary incontinence after surgery, with continence rates improving significantly over a year post-operation.*
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  • The study aimed to assess the safety and cosmetic benefits of laparoendoscopic single-site surgery (LESS) compared to traditional laparoscopic surgery for urachal remnants treatment.
  • Researchers reviewed medical records of 20 patients who had undergone either LESS or conventional surgery, analyzing factors like surgical time, blood loss, and postoperative pain.
  • Results indicated that while the operative metrics were similar, LESS resulted in shorter incision lengths and lower postoperative pain, suggesting it may be a viable alternative.
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  • Sarcopenia is the involuntary loss of muscle mass and strength that generally occurs with aging, and this study focused on kidney transplant recipients to compare physical activity levels between those with sarcopenia and those without.
  • The study involved 58 participants, categorized into three groups based on muscle mass and function: 20.7% (Group 1) with sarcopenia, 43.1% (Group 2) with presarcopenia, and 36.2% (Group 3) non-sarcopenia, using the International Physical Activity Questionnaire for assessment.
  • Results showed that physical activity was significantly lower in the sarcopenia and presarcopenia groups compared to the non
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The laparoscopic management of urachal remnants has gradually become a common practice. Recently, laparoscopic single-site surgery (LESS), a minimally invasive approach that provides excellent cosmetic results, has been adopted in several surgical procedures for treating urachal remnants. However, when suturing the bladder wall or peritoneal defect during LESS it may be difficult to conduct the procedure manually, and such cases require an additional port for suturing.

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Monoclonal gammopathy of undetermined significance (MGUS) is the common pre-malignant B cell disorders with a general prevalence of 3-5 % at age over 50. Because of the potential malignant transformation and immune insufficiency, pre-transplant MGUS recipient should be carefully followed after allograft transplantation. The post-transplant prognosis and quality of life (QOL) in patient with MGUS have not yet been fully determined.

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Objective: This study aimed to evaluate the relationship between sexual activity and sexual function using questionnaires distributed to middle-aged Japanese patients with localized prostate cancer.

Methods: A total of 145 patients who underwent radical prostatectomy were enrolled in the survey reported on herein. Sexual activity and sexual function were investigated via the Expanded Prostate Cancer Index Composite (EPIC) and an original self-reported questionnaire.

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Article Synopsis
  • The study compared the effectiveness of the enhanced recovery after surgery (ERAS) protocol against a conventional protocol for patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP).
  • A total of 198 patients were analyzed, with 123 receiving conventional care and 75 following the ERAS protocol, focusing on the time to first defecation as the primary outcome.
  • Results indicated that patients in the ERAS group experienced a significantly quicker time to first defecation and did not face major complications, suggesting ERAS may be a superior approach for recovery.
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Objective: The aim of this study was to evaluate and compare the cosmetic outcomes of laparoscopic single-site surgery (LESS) and conventional laparoscopy (CL) in the treatment of ureteropelvic junction obstruction (UPJO) and urachal remnant removal. LESS is thought to produce better cosmetic results than CL; however, patients' perception of their scars has not been assessed. This study compared the subjective body image and cosmesis ratings of patients who had undergone LESS or CL for UPJO and urachal remnant removal.

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Purpose: Urinary biomarkers of renal injury urinary may identify loss of renal function following nephron-sparing surgery (NSS). This study was designed to evaluate whether urinary l-type fatty acid-binding protein (l-FABP) is an early biomarker of loss of renal function after NSS. Specifically, the kinetics of urinary l-FABP level after NSS and its correlation with factors related to ischemic renal injury were analyzed.

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  • - This study analyzed the effects of renin-angiotensin system inhibitors on bladder cancer patients who underwent radical cystectomy, focusing on their overall and cancer-specific survival rates.
  • - In a group of 269 patients, those treated with these inhibitors had significantly better 5-year survival rates compared to those who were not treated (79.0% vs. 66.4% for cancer-specific survival).
  • - The findings suggest that renin-angiotensin system inhibitors could play a crucial role in improving survival outcomes for high-risk bladder cancer patients post-surgery.
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  • A study from Japan analyzed non-robotic laparoendoscopic single-site surgeries across nine institutions, focusing on outcomes like surgery conversions and complications from February 2009 to December 2012.
  • A total of 469 surgeries were examined, with adrenalectomy and radical nephrectomy being the most common procedures, and the majority of surgeries using a transperitoneal approach.
  • The overall conversion rate was 8.7%, with a low intraoperative complication rate of 2.1% and no recorded mortality, suggesting that this type of surgery is safe and effective for urologic conditions.
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Objective: To assess the prognostic value of perioperative changes in the neutrophil-lymphocyte ratio in patients with bladder cancer undergoing radical cystectomy.

Methods: We performed a retrospective analysis of 323 patients who had undergone radical cystectomy at our institutions. Overall survival was assessed with the Kaplan-Meier method and Cox regression analysis.

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