Publications by authors named "Masa Zrimsek"
Histone deacetylases (HDACs) target acetylated lysine residues in histone and non-histone proteins. HDACs are implicated in the regulation of genomic stability, cell cycle, cell death and differentiation and thus critically involved in tumorigenesis. Further, HDACs regulate T-cell development and HDAC inhibitors (HDACis) have been approved for clinical use in some T-cell malignancies.
View Article and Find Full Text PDFMalignant transformation depends on genetic and epigenetic events that result in a burst of deregulated gene expression and chromatin changes. To dissect the sequence of events in this process, we used a T-cell-specific lymphoma model based on the human oncogenic nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) translocation. We find that transformation of T cells shifts thymic cell populations to an undifferentiated immunophenotype, which occurs only after a period of latency, accompanied by induction of the MYC-NOTCH1 axis and deregulation of key epigenetic enzymes.
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- MicroRNAs (miRNAs) are small RNA molecules that help regulate gene expression after transcription, and variations in miRNA sequences can influence disease risk, including osteoporosis.
- This study aimed to identify specific miRNAs linked to bone mineral density (BMD) by analyzing recent genome-wide association studies (GWAS) data, finding a significant association with the variant rs11614913:C > T affecting BMD in the femoral neck and lumbar spine.
- The analysis revealed that the association with BMD was sex-specific, occurring only in women, and highlighted potential target genes in bone that may mediate miRNA functions related to BMD variations.