Computer simulations for internal dosimetry using voxel models.

In the Japan Atomic Energy Agency, several studies have been conducted on the use of voxel models for internal dosimetry. Absorbed fractions (AFs) and S values have been evaluated for preclinical assessments of radiopharmaceuticals using human voxel models and a mouse voxel model. Computational calibration of in vivo measurement system has been also made using Japanese and Caucasian voxel models.

Evaluation of counting efficiencies of a whole-body counter using Monte Carlo simulation with voxel phantoms.

In the 2007 recommendations of the International Commission on Radiological Protection, it is mentioned that the reference voxel phantoms are used for calculation of effective dose. From the standpoint of internal dosimetry services, calibration methods of whole-body counters using the voxel phantoms are of considerable practical interest. In the present study, counting efficiencies of a whole-body counter at the Japan Atomic Energy Agency (JAEA) were evaluated using Monte Carlo simulations with two voxel phantoms, 'MAX06', which has organ masses corresponding to those of the reference male, and 'Otoko', which is a representation for average Japanese male.

The structure of human apolipoprotein E2, E3 and E4 in solution. 2. Multidomain organization correlates with the stability of apoE structure.

The stabilities toward thermal and chemical denaturation of three recombinant isoforms of human apolipoprotein E (r-apoE2, r-apoE3 and r-apoE4), human plasma apoE3, the recombinant amino-terminal (NT) and the carboxyl-terminal (CT) domains of plasma apoE3 at pH 7 were studied using near and far ultraviolet circular dichroism (UV CD), fluorescence and size-exclusion chromatography. By far UV CD, thermal unfolding was irreversible for the intact apoE isoforms and consisted of a single transition. The r-apoE3 was found to be less stable as compared to the plasma protein and the stability of recombinant isoforms was r-apoE4 View Article and Find Full Text PDF