Publications by authors named "Masa Miscevic"
Article Synopsis
- Tolerance to a substance requires increasing amounts of it over time to achieve the same effects, but the mechanisms behind this process are not fully understood.
- Researchers are using Drosophila melanogaster (fruit flies) to study tolerance, as they share genetic similarities with humans that are relevant to alcohol responses and disorders.
- The study reveals an inverse relationship between initial resistance to ethanol and tolerance development, suggesting that some mutants may display 'secondary' tolerance due to their initial sensitivity, and it proposes a new method for evaluating tolerance that takes this relationship into account.
Terminating a meal after achieving satiation is a critical step in maintaining a healthy energy balance. Despite the extensive collection of information over the last few decades regarding the neural mechanisms controlling overall eating, the mechanism underlying different temporal phases of eating behaviors, especially satiation, remains incompletely understood and is typically embedded in studies that measure the total amount of food intake. In this review, we summarize the neural circuits that detect and integrate satiation signals to suppress appetite, from interoceptive sensory inputs to the final motor outputs.
View Article and Find Full Text PDFArticle Synopsis
- Tolerance requires increased substance amounts after initial exposure to achieve the same effects.
- Researchers have studied model organisms, like fruit flies, to understand tolerance due to their relevance to human alcohol responses and overlapping genetic factors.
- This study reveals an inverse relationship between initial resistance to alcohol and tolerance, suggesting that measuring tolerance should focus on relative change in sedation time, and offers a method to evaluate potential tolerance mutants using linear regression analysis.