Opportunities and challenges in stem cell therapy in cardiovascular diseases: Position standing in 2022.

This study intends to evaluate the development, importance, pre-clinical and clinical study evaluation of stem cell therapy for the treatment of cardiovascular disease. Cardiovascular disease is one of the main causes of fatality in the whole world. Though there are great progressions in the pharmacological and other interventional treatment options, heart diseases remain a common disorder that causes long-term warnings.

Proniosome: A Promising Approach for Vesicular Drug Delivery.

Different types of drug delivery systems are intended to deliver therapeutic agents to the appropriate site of interest to get desired pharmacological effect. In the field of drug delivery, the advancement of nanotechnology helps develop novel dosage forms such as liposome, noisome, and proniosome. Proniosomes are promising drug carriers, that are dry formulations, and after hydration, are converted to noisome dispersion.

Sedative and anxiolytic effects of ethanolic extract of Calotropis gigantea (Asclepiadaceae) leaves.

Objective: To evaluate possible anxiogenic activity, sedative property and anxiolytic potential of crude ethanolic extract of Calotropis gigantea leaves.

Methods: The anxiogenic activity of crude ethanolic extract of Calotropis gigantea leaves was evaluated using standard animal behavioral models, such as hole cross and open field; sedative property and anxiolytic potential were evaluated by conducting thiopental sodium induced sleeping time tests and elevated plus-maze test.

Results: The crude ethanolic extract exhibited a significant (P<0.