Electronic and steric substituent effects on the fluorescence emission of 2-pyrazoline derivatives.

A series of substituted 2-pyrazolines were synthesized, and the steric and electronic effects of substituents on the C - and C -positions of the heterocyclic ring on their fluorescent ability were investigated. Two different conjugative intramolecular charge transfer (ICT) and intramolecular charge transfer through space (spiro-conjugation) affect the fluorescence intensity of these compounds. The extent of the ICT process and spiro-conjugation depends on the electronic nature of the additional substitution and its position on the attached aryl rings.

Machine learning-based demand forecasting in cancer palliative care home hospitalization.

Objective: To develop an effective Management Information System (MIS) that is empowered by predictive models that can forecast the demand of end-stage cancer home hospitalized patients in individual and population levels, and help palliative care service systems operate smoothly where the demand is highly fluctuating, resources are limited, expensive, and hardly adjustable in a short time, and the backlog and shortage costs are high.

Method: Inspired by real problems faced by a palliative care center providing various medical, nursing, psychological, and social services in a home-based setting, two Long Short-Term Memory (LSTM) based deep learning models are proposed for demand forecasting at both individual and population levels. The individual-level model can predict the type and time of the next service required for a specific patient with a given demographic and health profile, and the population-level model helps with the prediction of next week's demand for various services in a center supporting a specific patient population.

Cyclic Voltammetric Study of 3,5-Diaryl-1-phenyl-2-pyrazolines.

Cyclic voltammetry is used to derive HOMO energies of the 1-phenyl-2-pyrazolines containing electron-donating or electron-withdrawing substituted phenyl rings and or naphthalenyl substitution on the C- or C-positions of the heterocyclic ring to investigate the steric and electronic effects of the aryl substitutions and the type of aryl system on their electrochemical behaviors. The optical HOMO-LUMO gaps needed for the calculation of LUMO (excited state) energies of these compounds are obtained from their UV-vis spectra. Results show that the substitution on the C-aryl ring has significant effect via its π-donor/acceptor ability, compared to the σ-donor/acceptor ability of the C-aryl ring, on the CV oxidation peak and onset potentials.

The impact of emotionally focused therapy on emotional distress in infertile couples.

Background: The present study investigated the effect of emotionally focused therapy (EFT) on factors contributing to emotional distress among infertile couples.

Materials And Methods: In this semi-experimental study, the subjects consisted of 12 Iranian couples: six infertile men and six infertile women. They were assessed as depressed, anxious and stressful individuals using depression, anxiety and stress scale (DASS).