Vortex fluidic regulated phospholipid equilibria involving liposomes down to sub-micelle size assemblies.

Conventional channel-based microfluidic platforms have gained prominence in controlling the bottom-up formation of phospholipid based nanostructures including liposomes. However, there are challenges in the production of liposomes from rapidly scalable processes. These have been overcome using a vortex fluidic device (VFD), which is a thin film microfluidic platform rather than channel-based, affording ∼110 nm diameter liposomes.

Pathway complexity in fibre assembly: from liquid crystals to hyper-helical gelmorphs.

Pathway complexity results in unique materials from the same components according to the assembly conditions. Here a chiral acyl-semicarbazide gelator forms three different gels of contrasting fibre morphology (termed 'gelmorphs') as well as lyotropic liquid crystalline droplets depending on the assembly pathway. The gels have morphologies that are either hyperhelical (HH-Gel), tape-fibre (TF-Gel) or thin fibril derived from the liquid crystalline phase (LC-Gels) and exhibit very different rheological properties.

Structural insights into self-assembly of a slow-evolving and mechanically robust supramolecular gel time-resolved small-angle neutron scattering.

The supramolecular assembly process is a widespread phenomenon found in both synthetically engineered and naturally occurring systems, such as colloids, liquid crystals and micelles. However, a basic understanding of the evolution of self-assembly processes over time remains elusive, primarily owing to the fast kinetics involved in these processes and the complex nature of the various non-covalent interactions operating simultaneously. With the help of a slow-evolving supramolecular gel derived from a urea-based gelator, we aim to capture the different stages of the self-assembly process commencing from nucleation.

Structural alterations of branched linear mixed-surfactant micellar systems with the addition of a complex perfume mixture and dipropylene glycol as cosolvent.

Personal care products commonly contain perfume mixtures, consisting of numerous perfume raw materials (PRMs), and cosolvents. The lipophilicity and structure of an individual PRM is known to affect its localization within the surfactant self-assembly as well as the micellar geometry. However, because multiple PRMs are used in formulations, significant intermolecular interactions between the PRMs and between the PRMs and the surfactant tail may also influence the location of the PRMs and their effects on the self-assembly.

Investigating the effect of a simplified perfume accord and dilution on the formation of mixed-surfactant microemulsions.

The phase analysis of a mixed surfactant system is much more complex than that for a single surfactant system. The addition of fragrance further enhances the complexity of such colloidal systems. The wide variation in structure and log  values of perfume raw materials influence its partitioning into the micellar phase.

Manipulating Assemblies in Metallosupramolecular Gels, Driven by Isomeric Ligands, Metal Coordination, and Adaptive Binary Gelator Systems.

Metallosupramolecular gel (MSG) is a unique combination of metal-ligand coordination chemistry and supramolecular gel chemistry with extraordinary adaptivity and softness. Such materials find broad uses in industry, pharmaceutical and biomedical sectors, and in technology generation among many others. Pyridyl-appended bis(urea) gelator systems have been extensively studied as potential MSG-forming materials in the presence of various metal ions.

Effects of a Multicomponent Perfume Accord and Dilution on the Formation of ST2S/CAPB Mixed-Surfactant Microemulsions.

Perfume mixtures contain perfume raw materials (PRMs) with varying structures and hydrophobicities, which influence PRM localization within a surfactant-based formulation and thereby affect the phase behavior. In rinse-off products, the addition of water can further affect the phase behavior. In this study, a mixture of 12 PRMs was used as the oil phase in an aqueous system consisting of sodium trideceth-2 sulfate as a primary surfactant, cocamidopropyl betaine as a cosurfactant, and dipropylene glycol as a cosolvent.

Vortex fluidic mediated encapsulation of functional fish oil featuring in situ probed small angle neutron scattering.

Major challenges for optimizing the benefits of fish oil on human health are improved bioavailability while overcoming the strong odor and avoiding significant oxidation of the omega-3 polyunsaturated fatty acids (PUFAs). The scalable continuous flow thin film vortex fluidic device (VFD) improves the Tween 20 encapsulation of fish oil relative to conventional homogenization processing, with the fish oil particles significantly smaller and the content of the valuable omega-3 fatty acids higher. In addition, after 14 days storage the remaining omega-3 fatty acids content was higher, from ca 31.

Differential behavior of sodium laurylsulfate micelles in the presence of nonionic polymers.

Hypothesis: Theory and practice have proven that the cleansing properties and irritation potential of surfactants can be controlled with the addition of co-surfactants or polymers. The size of the surfactant-polymer nanoassembly, which differs from the pure surfactant micelle, has been postulated to be the cause of the differences in a surfactant system's ability to disrupt the skin barrier. However, a firm structure-function relationship connecting polymer and surfactant under a consumer relevant condition is yet to be established.

Phase dependent structural perturbation of a robust multicomponent assembled icosahedral array.

We report on the assembly of three-fold axially compressed icosahedral arrays of the bowl shaped p-sulfonatocalix[4]arene molecules in the solid-state, intricately bound to dipicolinate and yttrium(iii) ions, with the compression reflected in Hirshfeld surface analyses. Solution studies show dissolution of the icosahedra intact, but with a geometrical rearrangement to regular icosahedra.

Bowl-in-bowl complex formation with mixed sized calixarenes: adaptivity towards guest binding.

We demonstrated the organization of two differently sized calixarenes C-methylresorcin[4]arene (RsC1) and either calix[6]arene (Calix6) or calix[8]arene (Calix8), where the lower rim of RsC1 partially overlaps with the upper rim of Calix6 or Calix8. An adaptive nature of the heteromacrocyclic assembly towards the binding of a model guest has been observed.