Publications by authors named "Marzieh L Sargazi"
Article Synopsis
- Breast cancer is a prevalent disease among women, and this study focuses on how curcumin, a natural compound, interacts with specific microRNAs (miR-221 and miR-222) and the Wnt/β-catenin signaling pathway in breast cancer cell lines.* -
- The researchers developed chitosan-curcumin nanoparticles (CC-CUR) to enhance the effects of curcumin, and they investigated its cytotoxicity and impact on gene expression in different breast cancer cell lines (MCF-7, MDA-MB-231, SK-BR-3).* -
- Results showed that CC-CUR reduced miR-221 and miR-222 levels and affected the Wnt/
Background And Aims: Coronary artery disease (CAD) is a devastating illness and primary cause of death worldwide that arises from a combination of genetic and environmental factors. Several large-scale studies found that 9p21.3, superoxide dismutase 2 (SOD2), and paraoxonase 1 (PON1) polymorphisms increase type 2 diabetes mellitus (T2DM) and/or coronary artery disease (CAD) risk.
View Article and Find Full Text PDFHedgehog (Hh) is a conserved signaling pathway that is involved in embryo development as well as adult tissue maintenance and repair in invertebrates and vertebrates. Abnormal activation of this pathway in various types of malignant drug- and apoptosis-resistant tumors has made it a therapeutic target against tumorigenesis. Thus, understanding the molecular mechanisms that promote the activation or inhibition of this pathway is critical.
View Article and Find Full Text PDFObjective: Gliomas are the most prevalent type of malignant primary brain tumors. Despite the availability of several treatment modalities, these tumors have poor prognostic features. Aberrant Hedgehog (Hh) signaling has been found to be implicated in the development of numerous malignancies including gliomas.
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