Evaluating the Protective Effects of Thymoquinone on Methamphetamine-induced Toxicity in an Model Based on Differentiated PC12 Cells.

Methamphetamine (Meth) is a highly addictive stimulant. Its potential neurotoxic effects are mediated through various mechanisms, including oxidative stress and the initiation of the apoptotic process. Thymoquinone (TQ), obtained from seed oil, has extensive antioxidant and anti-apoptotic properties.

Effect of cyanocobalamin (vitamin B12) on paraquat-induced brain injury in mice.

Objectives: The goal of this study was to evaluate the neuroprotective effects of vit B12 on paraquat-induced neurotoxicity.

Materials And Methods: Thirty-six male mice were randomly divided into six groups. Three groups were treated intraperitoneally with paraquat (10 mg/kg) twice a week (with a 3-day interval) for 3 weeks.