High Selectivity in Csp-Csp versus Csp-O Reductive Elimination from Cycloplatinated(IV) Complexes.

The cycloplatinated(IV) complexes -[Pt(-MeCH)(CN)(OAc)(HO)] (CN = benzo[h]quinolate, bhq, , and 2-phenylpyridinate, ppy, ) were prepared by reacting the corresponding [Pt(-MeCH)(CN)(SMe)] precursors with PhI(OAc) through an oxidative addition (OA) reaction. Thermolysis of at 65 °C generates -[Pt(κN-10-(-MeCH)-bhq)(OAc)(HO)], , which is the product of a Csp-Csp reductive elimination (RE). The observed coupling reaction is significantly different from the previously reported analogous thermolysis of -[PtMe(CN)(OAc)(HO)] (CN = bhq, , and ppy, ) that selectively releases Me-OAc (C-O RE).

Oxidative Addition of a Hypervalent Iodine Compound to Cycloplatinated(II) Complexes for the C-O Bond Construction: Effect of Cyclometalated Ligands.

The complex [PtMe(Obpy)(OAc)(HO)], , Obpy = 2,2'-bipyridine -oxide, is prepared through the reaction of [PtMe(Obpy)(SMe)], , by 1 equiv of PhI(OAc) via an oxidative addition (OA) reaction. Pt(IV) complex attends the process of C-O bond reductive elimination (RE) reaction to form methyl acetate and corresponding Pt(II) complex [Pt(Obpy)(OAc)(HO)], . The kinetic of OA and RE reactions are investigated by means of different spectroscopies.

Origami paper analytical assay based on metal complex sensor for rapid determination of blood cyanide concentration in fire survivors.

Cyanide-based blood poisoning can seriously damage fire victims and cause death if not detected quickly. Previous conventional methods require laboratory equipment, which are expensive and increase the duration of the analysis. Here, a simple origami based microfluidic device was introduced for point of need detection of blood cyanide concentration in people involved in fire.

Investigations of antiproliferative and antioxidant activity of β-lactam morpholino-1,3,5-triazine hybrids.

This article reports for the first time the synthesis of some novel β-lactam morpholino-1,3,5-triazine hybrids by a [2+2]-cycloaddition reaction of imines 7a-c, 9a-c and 11 with ketenes derived from substituted acetic acids. The reaction was totally diastereoselective, leading exclusively to the formation of cis-β-lactams 8a-l, 10a-f and 12a-c. The synthesized compounds were tested for activity towards SW1116, MCF-7 and HepG2 cancer cell lines and non-cancerous HEK-293 cell line by MTT assay.

Cycloplatinated(II) Derivatives of Mercaptopurine Capable of Binding Interactions with HSA/DNA.

In this study, two new bis-cyclometalated Pt(II) complexes, [Pt(C^N)(S^N)] [S^N = deprotonated 6-mercaptopurine (6-MP) and C^N = deprotonated 2-phenylpyridine (ppy), ; C^N = deprotonated benzo[]quinoline (bhq), ], are synthesized by the reaction of [PtR(SMe)(C^N)] (R = Me or -MeCH) with 1 equiv of 6-mercaptopurine (6-HMP) at room temperature. The complexes are fully characterized using H and C NMR spectroscopies, electrospray ionization mass spectrometry, and elemental analysis. Biomolecular interaction of complex with human serum albumin (HSA) is studied by fluorescence, UV-vis, and circular dichroism (CD) spectroscopies.

Comparative study on the interaction of two binuclear Pt (II) complexes with human serum albumin: Spectroscopic and docking simulation assessments.

Human serum albumin (HSA) principally tasks as a transport carrier for a vast variety of natural compounds and pharmaceutical drugs. In the present study, two structurally related binuclear Pt (II) complexes containing cis, cis-[MePt (μ-NN) (μ-dppm) PtMe] (1), and cis, cis-[MePt(μ-NN)(μ dppm) Pt((CH))] (2) in which NN=phthalazine and dppm=bis (diphenylphosphino) methane were used to investigate their interaction with HSA, using UV-Vis absorption spectroscopy, fluorescence, circular dichroism and molecular dynamic analyses. The spectroscopic results suggest that upon binding to HSA, the binuclear Pt (II) complexes could effectively induce structural alteration of this protein.

Anticancer activity assessment of two novel binuclear platinum (II) complexes.

In the current study, two binuclear Pt (II) complexes, containing cis, cis-[Me2Pt (μ-NN) (μ-dppm) PtMe2] (1), and cis,cis-[Me2Pt(μ-NN)(μ dppm) Pt((CH2)4)] (2) in which NN=phthalazine and dppm=bis (diphenylphosphino) methane were evaluated for their anticancer activities and DNA/purine nucleotide binding properties. These Pt (II) complexes, with the non-classical structures, demonstrated a significant anticancer activity against Jurkat and MCF-7 cancer cell lines. The results of ethidium bromide/acridine orange staining and Caspase-III activity suggest that these complexes were capable to stimulate an apoptotic mechanism of cell death in the cancer cells.

Promoting C-C Bond Coupling of Benzyne and Methyl Ligands in Electron-Deficient (triphos)Pt-CH Complexes.

In situ generated benzyne reacts at room temperature with (triphos)Pt-CH to form a five-coordinate π-complex () that is isolable and stable in solution. Thermolysis of at 60 °C generates (triphos)Pt(o-tolyl) (), which is the product of formal migratory insertion of CH onto the coordinated benzyne. The reaction of with the acid PhNH yields toluene at room temperature over the course of 8 h, while the same reaction with only proceeds to 40% conversion over 2 days.

DNA Binding and Anticancer Activity of Novel Cyclometalated Platinum (II) Complexes.

This study describes anticancer activity and DNA binding properties of two cyclometalated platinum (II) complexes with non-leaving lipophilic ligands; deperotonated 2-phenylpryidine (ppy): C1 and deperotonated benzo[h]quinolone (bhq): C2. Both complexes demonstrate significant anticancer activity and were capable to stimulate Caspase-III activity in Jurkat cancer cells. The results of Acridine orange/Ethidium bromide(AO/EtB), along with those of Caspase-III activity suggest that these complexes can induce apoptosis in the cancer cells.

DNA binding and anticancer activity of novel cyclometalated platinum (II) complexes.

This study describes anticancer activity and DNA binding properties of two cyclometalated platinum (II) complexes with non-leaving lipophilic ligands; deprotonated 2-phenylpryidine (ppy): C1 and deprotonated benzo[h] quinolone (bhq): C2. Both complexes demonstrate significant anticancer activity and were capable to stimulate Caspase-III activity in Jurkat cancer cells. The results of Acridine orange/Ethidium bromide(AO/EtB), along with those of Caspase-III activity suggest that these complexes can induce apoptosis in the cancer cells.

Anion-Dependent Switch in C-X Reductive Elimination Diastereoselectivity.

Reaction of a complex Pt organometallic species with electrophilic halogen sources in the presence of X ligands changes the mechanism of reductive elimination from a concerted reductive coupling type to an S2 type reductive elimination. In the absence of the added X ligand the reductive elimination is stereoretentive; in its presence, the process is stereoinvertive. This selectivity hinges on the reactivity of a key five-coordinate Pt(IV) intermediate with the X ligand.