Publications by authors named "Marzia Tina Indrigo"
Article Synopsis
- - Rett syndrome is an incurable disorder caused by mutations in the MeCP2 gene, which can lead to neurological issues when overexpressed.
- - Researchers developed a gene therapy using a specific viral vector (AAV-PHP.eB) that delivers a modified transgene to maintain proper levels of the MeCP2 protein, which improved symptoms in mice.
- - While the therapy worked well for female mutant and wild-type mice, male mutant mice showed a strong immune response that required immunosuppression to address.
Article Synopsis
- Ras-ERK signaling in the brain is crucial for understanding drug addiction, but no effective inhibitors have been tested in addiction models yet.
- Researchers developed two peptides, RB1 and RB3, that can penetrate the brain and inhibit key cellular processes related to ERK signaling.
- The study identified PD325901, a drug already in cancer clinical trials, which effectively blocks ERK signaling and reduces cocaine-related behaviors in mice, suggesting it could be useful for treating cocaine addiction.
