Publications by authors named "Marzhan Urazbayeva"
Advances in Ketogenic Diet Therapies in Pediatric Epilepsy: A Systematic Review.
Prim Care Companion CNS Disord
June 2024
Article Synopsis
- A review was conducted on the impact of the ketogenic diet on epilepsy treatment in children and adolescents, following systematic guidelines and including 12 qualifying studies.
- The ketogenic diet showed positive results in reducing the frequency and severity of seizures while presenting manageable side effects like gastrointestinal issues and dehydration.
- Variations of the ketogenic diet were found beneficial for seizure management, serving as either a complementary or alternative treatment for young patients with epilepsy.
Article Synopsis
- Islet autoantibodies are crucial for diagnosing and understanding the variability in type 1 diabetes (T1D) progression and response to treatments.
- A review of 152 studies indicated that the majority focused on autoantibody characteristics before T1D diagnosis, highlighting correlations between autoantibody types, numbers, and disease progression.
- The findings emphasize the need for precise definitions of T1D based on autoantibodies and suggest improving research methods through standardization to enhance the effectiveness of precision medicine in T1D.
Article Synopsis
- Precision medicine is an evolving approach in healthcare that aims to enhance decision-making and health outcomes, particularly in managing diabetes, which poses serious health risks for millions globally.
- The second international consensus report on precision diabetes medicine reviews current findings on prevention, diagnosis, treatment, and prognosis across different forms of diabetes, highlighting the potential for translating research into clinical practice.
- The report also identifies knowledge gaps and sets out key milestones for better clinical implementation, emphasizing the need for standards addressing cost-effectiveness, health equity, and accessibility in treatment options.
Background: Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneity in disease progression and therapy response has limited translation to clinical practice, highlighting the need for precision medicine approaches to T1D disease modification.
Methods: To understand the state of knowledge in this area, we performed a systematic review of randomized-controlled trials with ≥50 participants cataloged in PubMed or Embase from the past 25 years testing T1D disease-modifying therapies and/or identifying features linked to treatment response, analyzing bias using a Cochrane-risk-of-bias instrument.
Background: The greatest change in the treatment of people living with type 1 diabetes in the last decade has been the explosion of technology assisting in all aspects of diabetes therapy, from glucose monitoring to insulin delivery and decision making. As such, the aim of our systematic review was to assess the utility of these technologies as well as identify any precision medicine-directed findings to personalize care.
Methods: Screening of 835 peer-reviewed articles was followed by systematic review of 70 of them (focusing on randomized trials and extension studies with ≥50 participants from the past 10 years).
Article Synopsis
- Type 1 diabetes (T1D) is caused by immune system attacks on insulin-producing cells, prompting a need for personalized prevention strategies due to varying disease progression and treatment responses.
- Researchers conducted a systematic review of 75 studies over 25 years focused on therapies for T1D prevention and treatment, but found inconsistencies in how precision analyses were conducted, leading to challenges in clinical application.
- Future studies should ensure well-defined and thorough precision analyses to enhance the understanding and effectiveness of T1D prevention strategies.
Background: asthma, a chronic respiratory disease caused by inflammation and narrowing of the small airways in the lungs, is the most common chronic childhood disease. Prevalence of childhood asthma in the United States is 5.8%.
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