Publications by authors named "Maryse Wanlin"
Belgium is a country with low incidence of tuberculosis (TB) and a very low number of TB cases in children. Children in contact with an adult smear-positive TB case are at high risk of transmission. Early diagnosis is important as young children have a significant predisposition of developing TB disease.
View Article and Find Full Text PDF: To review the current knowledge on screening for latent tuberculosis infection (LTBI) in HIV-infected adults and provide specific guidelines for Belgium. Focus is given to who to test, which testing method to use, timing of screening and choice of LTBI treatment. : Expert review by the members of the Belgian LTBI group, in consultancy with the ARC College.
View Article and Find Full Text PDFArticle Synopsis
- The TB incidence rate in the Brussels-Capital Region is significantly higher (3-fold) than in the rest of Belgium, prompting ongoing genetic studies of TB strains from local patients.
- The study, which included genotyping of strains from 945 patients, identified LAM and Haarlem as the most prevalent TB lineages, with a notable presence of Beijing strains among the MDR subgroup, especially in Eastern European patients.
- Despite a high proportion of foreign-born patients (75.7%), the analysis reveals limited trans-national transmission, and overall, the epidemiological situation appears stable, emphasizing the need for funding to support ongoing TB control efforts through molecular epidemiology.
Objectives: Currently, there are no European data about the frequency and clinical significance of nontuberculous mycobacteria (NTM) grown from respiratory samples during the treatment of tuberculosis (TB). We determined the frequency and clinical significance of NTM isolated before or during pulmonary tuberculosis treatment in Belgian laboratories.
Methods: We conducted a nationwide retrospective multicenter cohort study on the co-isolation of TB and NTM in Belgium.
Article Synopsis
- - This paper introduces an action framework designed for countries with low tuberculosis (TB) incidence aiming to eliminate the disease, emphasizing a step-by-step approach towards "pre-elimination" and eventual complete elimination of TB.
- - The framework identifies challenges faced by low-incidence countries, such as decreased political commitment, funding, and awareness as TB rates decline, along with issues related to vulnerable populations and cross-border migration.
- - Eight priority action areas are outlined to tackle these challenges, including ensuring political support, addressing the needs of at-risk groups, and investing in research, all while emphasizing a multisectoral approach to ensure equitable access to TB diagnosis and treatment.
Without better vaccines it is unlikely that tuberculosis (TB) will ever be eliminated. An investment of ∼ €560 million is considered necessary to develop a new, effective vaccine in the European Union (EU). However, less is known about the costs of TB disease in the EU.
View Article and Find Full Text PDFBackground: Emergence of extensively drug-resistant tuberculosis (XDR-TB) represents an enormous challenge to Public Health globally.
Methods: Progression towards XDR-TB was investigated in Belgium, a country with a typically low TB incidence, by analyzing the magnitude, characteristics, and treatment success of multidrug-resistant tuberculosis (MDR-TB) through a population-based study from 1994 to 2008.
Results: Among the 174 MDR-TB patients, 81% were foreign-born, 48% of these being asylum seekers.
Tuberculosis in healthcare workers caring for a congenitally infected infant.
Infect Control Hosp Epidemiol
December 2004
Objective: To assess the extent of nosocomial transmission of tuberculosis among infants, family members, and healthcare workers (HCWs) who were exposed to a 29-week-old premature infant with congenital tuberculosis, diagnosed at 102 days of age.
Design: A prospective exposure investigation using tuberculin skin test (IST conversion was conducted. Contacts underwent two skin tests 10 to 12 weeks apart.