Publications by authors named "Maryna M Kornet"
Article Synopsis
- Sequential Pd-catalyzed one-pot methods have become a key approach in organic synthesis, allowing for the efficient creation of complex heterocyclic compounds, with a focus on classic reactions like Suzuki-Miyaura and Heck.
- The review highlights advancements in these techniques, including collaborations with other metals (like copper and gold) to enhance the variety of synthesized heterocyclic derivatives, especially those with pharmaceutical significance.
- It emphasizes both the benefits of these strategies in terms of efficiency and eco-friendliness, while also acknowledging ongoing challenges and the need for further optimization in these synthetic processes.
Pyrazoles are rarely found in nature but are traditionally used in the agrochemical and pharmaceutical industries, while other areas of use are also actively developing. However, they have also found numerous other applications. The search for new and efficient syntheses of these heterocycles is therefore highly relevant.
View Article and Find Full Text PDFSubstituted 1-pyrazolo[3,4-]pyridine-4- and 1-pyrazolo[3,4-]pyridine-6-carboxamides have been synthetized through a Doebner-Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity.
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