THE RELATIONSHIPS OF IRS-1 POLYMORPHISM WITH HEMODYNAMIC DISORDERS IN HYPERTENSIVE PATIENTS DEPENDING ON BODY WEIGHT AND METABOLIC COMORBIDITY.

Objective: The aim: The aim was to study the relationships of IRS-1 gene polymorphism with indicators of the structural and functional state of the heart and blood vessels in patients with arterial hypertension under conditions of different metabolic comorbidity and body weight.

Patients And Methods: Materials and methods: We examined 340 patients with arterial hypertension with different body weight and different types of metabolic comorbidity and 30 healthy individuals aged 45-55. Anthropometric, Biochemical, Molecular genetic methods, Instrumental, Statistical methods were used.

ASTHMA IN A PATIENT WITH COVID-19: DOES IT PROTECT OR INCREASE THE RISKS?

Objective: The aim: To investigate theimpact of asthma co-morbidity on the susceptibility and clinical course of COVID-19 in asthma patients.

Patients And Methods: Materials and methods: Electronic databases of Pubmed and Google Scholar were searched using keyword searches.

Conclusion: Conclusions: Despite previous concerns about the increased risk of Covid-19 among asthmatics, most studies have not shown an increase in Covid-19 incidence among asthmatics compared to the general population.

Associations of irs-1 polymorphism with various components of the metabolic syndrome in hypertensive patients.

Introduction: The metabolic syndrome is one of the most discussed cross-disciplinary problems of modern medicine. Now there are various definitions and criteria of diagnostics of metabolic syndrome. The abdominal obesity is considered the main component of the metabolic syndrome, as a reflection of visceral obesity which degree is offered to be estimated on an indirect indicator – a waist circumference.

The Role of Genetic Polymorphism in the Formation of Arterial Hypertension, Type 2 Diabetes and their Comorbidity.

Background: Hereditary component plays a significant role in the formation of insulin resistance (IR) - one of the pathogenetic links of arterial hypertension (AH) and type 2 diabetes mellitus (DM2). However, the genetic predisposition to IR can not be realized and does not manifest itself clinically in the absence of appropriate factors of the environment (excessive nutrition, low physical activity, etc.).