[hrs Gene and Borders of Compartments of Imaginal Wing Disc in Drosophila melanogaster].

Hepatocyte growth factor receptor tyrosine kinase substrate (Hrs) is an endosome protein involved in the sorting and transport of receptor tyrosine kinases and other proteins (which are absorbed by the cell during endocytosis) from early endosomes to lysosomes. Since receptor tyrosine kinases are important components of different cellular signaling systems, Hrs protein defects can result in the appearance of a number of developmental anomalies. In particular, it was demonstrated that ectopic Hrs expression in the wing kidney results in the disappearance of one or several rows of marginal wing setae in imago (which indicates hrs gene involvement in the development of the disc D/V border).